Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells neurotoxicology study 英文参考文献.docVIP

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Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells neurotoxicology study 英文参考文献.doc

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Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells neurotoxicology study 英文参考文献

Environmental Health: A Global Access Science Source BioMedCentral Research Open Access Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study Eiichi Akahoshi, Seiko Yoshimura and Mitsuko Ishihara-Sugano* Address: Environmental Technology Laboratory, Corporate Research Development Center, Toshiba Corporation, 1 Komukai-Toshiba cho, Saiwai-ku, Kawasaki 212–8582, Japan Email: Eiichi Akahoshi - eiichi.akahoshi@toshiba.co.jp; Seiko Yoshimura - seiko.yoshimura@toshiba.co.jp; Mitsuko Ishihara- Sugano* - mitsuko.sugano@toshiba.co.jp * Corresponding author Published: 07 September 2006 Received: 10 April 2006 Accepted: 07 September 2006 Environmental Health: A Global Access Science Source 2006, 5:24 doi:10.1186/1476-069X-5- 24 This article is available from: /content/5/1/24 ? 2006 Akahoshi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Dioxins and related compounds are suspected of causing neurological disruption in human and experimental animal offspring following perinatal exposure during development and growth. The molecular mechanism(s) of the actions in the brain, however, have not been fully investigated. A major participant in the process of the dioxin-toxicity is the dioxin receptor, namely the aryl hydrocarbon receptor (AhR). AhR regulates the transcription of diverse genes through binding to the xenobiotic-responsive element (XRE). Since the AhR has also been detected in various regions of the brain, the AhR may play a key role in the developmental neurotoxicity of dioxins. This study focused on the effect of AhR activation in the developing neuron. Methods: The influence of the AhR on the