Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups 英文参考文献.docVIP

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Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups 英文参考文献.doc

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Over-Expression of Human Lipoprotein Lipase in Mouse Mammary Glands Leads to Reduction of Milk Triglyceride and Delayed Growth of Suckling Pups 英文参考文献

Over-ExpressionofHumanLipoproteinLipaseinMouse MammaryGlandsLeadstoReductionofMilkTriglyceride andDelayedGrowthofSucklingPups YuanyuanWang1,JiaTong1,ShupingLi1,RanZhang1,LiChen1,YuhuiWang2,MinZheng3,MeiliWang3, GeorgeLiu2,YunpingDai3,YaofengZhao1,NingLi1* 1State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China, 2Health Science Center, Institute of CardiovascularSciences,PekingUniversity,Beijing,China,3GenProteinBiotechLtd.,Beijing,China Abstract Background:Themammaryglandisaconservedsiteoflipoproteinlipaseexpressionacrossspeciesandlipoproteinlipase attachment to the luminal surface of mammary gland vascular endothelial cells has been implicated in the direction of circulatingtriglyceridesintomilksynthesisduringlactation. PrincipalFindings:Herewereportgenerationoftransgenicmiceharboringahumanlipoproteinlipasegenedrivenbya mammarygland-specificpromoter.Lipoproteinlipaselevelsintransgenicmilkwasraisedto0.16mg/ml,correspondingto anactivityof8772.95mU/ml.Highlipoproteinlipaseactivityledtoasignificantreductionoftriglycerideconcentrationin milk, but other components were largely unchanged. Normal pups fed with transgenic milk showed inferior growth performancescomparedtothosefedwithnormalmilk. Conclusion:Ourstudysuggestsapossibilitytoreducethetriglyceridecontentofcowmilkusingtransgenictechnology. Citation:WangY,TongJ,LiS,ZhangR,ChenL,etal.(2011)Over-ExpressionofHumanLipoproteinLipaseinMouseMammaryGlandsLeadstoReductionofMilk TriglycerideandDelayedGrowthofSucklingPups.PLoSONE6(6):e20895.doi:10.1371/journal.pone.0020895 Editor:VladimirN.Uversky,UniversityofSouthFloridaCollegeofMedicine,UnitedStatesofAmerica ReceivedFebruary28,2011;AcceptedMay12,2011;PublishedJune17,2011 Copyright: ? 2011 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourceare