Perturbation of Lytic and Latent Gammaherpesvirus Infection in the Absence of the Inhibitory Receptor CEACAM1 英文参考文献.docVIP

下载本文档

0
0
约5万字
约 12页
2017-05-12 发布于上海
举报
版权申诉

Perturbation of Lytic and Latent Gammaherpesvirus Infection in the Absence of the Inhibitory Receptor CEACAM1 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Perturbation of Lytic and Latent Gammaherpesvirus Infection in the Absence of the Inhibitory Receptor CEACAM1 英文参考文献

PerturbationofLyticandLatentGammaherpesvirus InfectionintheAbsenceoftheInhibitoryReceptor CEACAM1 HeikoAdler1.,SusanneEl-Gogo2.,SimoneGuggemoos1,WolfgangZimmermann3,NicoleBeauchemin4, RobertKammerer3,5 * 1Helmholtz Zentrum Mu¨nchen - National Research Center for Environmental Health, Institute of Molecular Immunology, CCG HCT, Munich, Germany, 2Institute of Virology,TechnicalUniversityMunich,Munich,Germany,3TumorImmunologyLaboratory,LIFECenter,KlinikumGrosshadern,Ludwig-Maximilians-University,Munich, Germany,4GoodmanCancerCentre,McGillUniversity,Montreal,Quebec,Canada,5InstituteofImmunology,Friedrich-Loeffler-Institut,Tuebingen,Germany Abstract Controlofgammaherpesvirusinfectionsrequiresacomplex,wellorchestratedimmuneresponseregulatedbypositiveand negativeco-signalingmolecules.Whiletheimpactofco-stimulatorymoleculeshasbeenaddressedinvariousstudies,the role of co-inhibitory receptors has not been tested. The ITIM-bearing CEACAM1 is an inhibitory receptor expressed by a varietyofimmunecells,includingB,TandNKcells.UsingCeacam12/2mice,weanalyzedtheinvivofunctionofCEACAM1 duringacuteandlatentmurinegammaherpesvirus68(MHV-68)infection.Duringacutelyticreplication,weobservedlower virustitersinthelungsofCeacam12/2micethaninWTmice.Incontrast,duringlatencyamplification,Ceacam12/2 mice displayedincreasedsplenomegalyandahigherlatentviralloadinthespleen.Analysisoftheimmuneresponserevealed increasedvirus-specificantibodylevelsinCeacam12/2mice,whilethemagnitudeoftheTcell-mediatedantiviralimmune responsewasreduced.Thesefindingssuggestthatinhibitory receptors canmodulatetheefficacy ofimmuneresponses againstgammaherpesvirusinfections. Citation:AdlerH,El-GogoS,GuggemoosS,ZimmermannW,BeaucheminN,etal.(2009)PerturbationofLyticandLatentGammaherpesvirusInfectioninthe AbsenceoftheInhibitoryReceptorCEACAM1.PLoSONE4(7):e6317.doi:10.1371/journal.pone.0006317 Editor:Jo¨rgHermannFritz,UniversityofToronto,Canada ReceivedFebruary3,2009;AcceptedJune19,2009;PublishedJuly21,2009 Copyright: ? 20