PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimers disease 英文参考文献.docVIP

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PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimers disease 英文参考文献.doc

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PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimers disease 英文参考文献

Pontecorvo and Mintun Alzheimer’s Research Therapy 2011,3:11 /content/3/2/11 REVIEW PET amyloid imaging as a tool for early diagnosis and identifying patients at risk for progression to Alzheimer’s disease Michael J Pontecorvo* and Mark A Mintun Nevertheless, there remains both room and a need for Abstract improvement in diagnostic accuracy. Up to 20% of Current theory suggests that β-amyloid accumulation may be an early step in the cascade that leads to cognitive impairment in Alzheimer’s disease. β-Amyloid targeted positron emission tomography (PET) imaging potentially provides a direct, relatively noninvasive estimate of brain β-amyloid burden. This has recently been supported by demonstration that amyloid plaque binding on PET was strongly correlated with brain β-amyloid burden at autopsy. Additionally, there is growing consensus that PET imaging can identify subjects with elevated β-amyloid burden, even at early stages of disease. Finally, preliminary evidence suggests that abnormal β-amyloid accumulation, as evidenced by PET imaging, has implications for both present and future cognitive performance. Although large longitudinal studies like the ongoing ADNI trial will be required for de?nitive evaluation, present data suggest that PET amyloid imaging has the potential to promote earlier and more speci?c diagnosis of dementia. subjects clinically diagnosed with AD do not have AD pathology at autopsy [4-6],a percentage that is essentially unchanged from the estimate in the 1984 consensus publication [1]. In addition, under-diagnosis in the commu nity setting is signi? cant. Approximately 10% of community-dwelling elderly have undiagnosed dementia [7,8] and community physicians may fail to diagnose up to 33% of individuals with mild dementia [8]. Perhaps the biggest limitation in current practice is a reliance on the presentation and progression of symptoms to identify an AD phenoty