Polymorphism in the MHC2TA Gene Is Associated with Features of the Metabolic Syndrome and Cardiovascular Mortality 英文参考文献.docVIP
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Polymorphism in the MHC2TA Gene Is Associated with Features of the Metabolic Syndrome and Cardiovascular Mortality 英文参考文献
PolymorphismintheMHC2TAGeneIsAssociatedwith
FeaturesoftheMetabolicSyndromeandCardiovascular
Mortality
EeroLindholm*,OlleMelander,PeterAlmgren,Go¨ranBerglund,Carl-DavidAgardh,LeifGroop,MarjuOrho-Melander
DepartmentofClinicalSciences,ClinicalResearchCenter,UniversityHospitalMalmo¨ (MAS),LundUniversity,Malmo¨,Sweden
Background. Recently, a -168ARG polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be
associatedwithincreasedsusceptibilitytomyocardialinfarction(MI).Aim.ToconfirmtheassociationbetweentheMHC2TA-
168ARG polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and
cardiovascularmortality.MaterialsandMethods.Usinganallelicdiscriminationmethodwegenotyped11,064individuals
fromthreestudypopulations:1)4,432individualsfromtheBotniatype2diabetes(T2D)study,2)1,222patientswithMIand
2,345 control subjects participating in the Malmo¨ Diet and Cancer study and comprising an MI case-control sample, and 3)
3,065T2DpatientsfromtheLocalSwedishDiabetesregistry.Results.Noassociationbetweenthe-168ARGpolymorphismin
MHC2TA and MI was observed. However, in the Botnia cohort the AG/GG genotypes were associated with cardiovascular
mortality after MI (1.78 [1.09–2.92], p=0.02). In addition, the AG/GG genotypes were more common in subjects with MetS
(40.1% vs. 36.9%, p=0.03) and in non-diabetic subjects with microalbuminuria (45.4% vs. 36.5%, p=0.003) compared to
control subjects. Conclusions. A polymorphism in MHC2TA was associated with cardiovascular mortality and predictors of
cardiovascularmortality,microalbuminuriaandMetS.
Citation: LindholmE,MelanderO,AlmgrenP,BerglundG,AgardhC-D,etal(2006)PolymorphismintheMHC2TAGeneIsAssociatedwithFeaturesof
theMetabolicSyndromeandCardiovascularMortality.PLoSONE1(1):e64.doi:10.1371/journal.pone.0000064
INTRODUCTION
MATERIALSANDMETHODS
CardiovasculardiseaseistheleadingcauseofdeathinSwedenand
inmostWesterncountries.Almost50%ofdeceasedindividualsdied
due to cardiovascular
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