Polymorphism rs4919510CG in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2-Positive Breast Cancer but Not Other Subtypes 英文参考文献.docVIP

Polymorphism rs4919510CG in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2-Positive Breast Cancer but Not Other Subtypes 英文参考文献.doc

  1. 1、本文档共8页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
  5. 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
  6. 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们
  7. 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
  8. 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Polymorphism rs4919510CG in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2-Positive Breast Cancer but Not Other Subtypes 英文参考文献

Polymorphismrs4919510:C.GinMatureSequenceof HumanMicroRNA-608ContributestotheRiskofHER2- PositiveBreastCancerbutNotOtherSubtypes A-JiHuang.,Ke-DaYu.,JingLi.,LeiFan,Zhi-MingShao* DepartmentofBreastSurgery,CancerCenterandCancerInstitute,ShanghaiMedicalCollege,FudanUniversity,Shanghai,People’sRepublicofChina Abstract Background: A few polymorphisms are located in the mature microRNA sequences. Such polymorphisms could directly affectthebindingofmicroRNAtohundredsoftargetmRNAs.Itremainsunknownwhetherrs4919510:C.Glocatedinthe maturemiR-608altersbreastcancersusceptibility. Methods:Theassociationofrs4919510:C.Gwithriskandpathologicfeaturesofbreastcancerwereinvestigatedintwo independentcase-controlstudies,thefirstsetincluding1,138sporadicbreastcancerpatients(including927invasiveductal carcinomapatients,777ofthemwithknownsubtypes:496luminal-like,133HER2-positive,and148triple-negative)and 1,434 community-based controls, and the second set including 294 familial/early-onset breast cancer patients and 500 hospital-basedcancer-freecontrols.Oddsratios(ORs)wereestimatedbylogisticregression.PredictedtargetsofmiR-608 andcomplementarysequencescontainingrs4919510:C.Gweresurveyedtorevealpotentialpathologicalmechanism. Results:Inthefirstset,althoughrs4919510:C.Gwasunrelatedtobreastcanceringeneralpatients,variantgenotypes(CG/ GG)werespecificallyassociatedwithincreasedriskofHER2-positivesubtype(AdjustedOR=1.97,95%CI,1.3422.90inthe recessivemodel).VariantG-allelewastheriskallelewithORof1.62(95%CI,1.2322.15).PatientscarryingGG-genotypealso had larger HER2-positive tumors (P for Kruskal-Wallis test=0.006). The relationship between rs4919510:C.G and risk of HER2-positivesubgroupwasvalidatedinthesecondset(BonferronicorrectedP=0.06).TheadjustedcombinedOR(total 164HER2-positivecases)intherecessivemodelwas1.97(95%CI,1.4322.72)forGGgenotype(correctedP=1.161024 ). Bioinformaticanalysisindicatedthat,HSF1,whichisrequiredforHER2-inducedtumorigenesis,mightbeatargetofmiR-608. Theminimumfree-energyofan

您可能关注的文档

文档评论(0)

sheppha + 关注
实名认证
文档贡献者

该用户很懒,什么也没介绍

版权声明书
用户编号:5134022301000003

1亿VIP精品文档

相关文档