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Porencephaly and psychosis a case report and review of the literature 英文参考文献
Douzenisetal.BMCPsychiatry2010,10:19
/1471-244X/10/19
CASE REPORT
OpenAccess
Porencephalyandpsychosis:acasereportand
reviewoftheliterature
AthanassiosDouzenis1*,EmmanouilNRizos1,AthanasiaPapadopoulou1,MatildaPapathanasiou2,
LefterisLykouras1
Abstract
Background:Malformationsofthecerebralcortexareoftenassociatedwithdevelopmentaldelayandpsychoses.
Porencephalyisararecongenitaldisorderofcentralnervoussysteminvolvingacystoracavityfilledwith
cerebrospinalfluid,inbrain’ sparenchyma.
Casepresentation:Wepresenta25yearsoldwomanwithherfirstpsychoticepisode.Shealsosuffersfrom
porencephalyinthefrontotemporallobesregion.Itisemphasizedthatthetwoconsistentlyabnormalbrain
regionsinschizophreniaresearchhadsignificantdamageinthispatientsincebirth.Thereisatotalofonlyfive
casesofschizencephalyorporencephalyassociatedwithpsychosisinthescientificliterature.Theirclinical
characteristicsaswellastheimagingresultsaredescribed.
Conclusion:Itisunclearifporencephalyandpsychosisconcurbychanceorarecausallyrelated.Theareawhere
theporencephaliccystsappearseemstobeofrelevance.Thiscasehighlightstheneedforfurtherresearch.
Background
disturbedprefrontalmetabolismandbloodflow.Aswell
Malformations of the cerebral cortex are often asso- asdecreasedhippocampalandentothinalcortexvolume,
ciated withdevelopmental delay andpsychoses. Poren- inpsychoticpatients,havebeendemonstrated.Allthese
cephaly is an extremely rare congenital disorder of the arestrongindicationsthatprefrontalcorticalandmedial
centralnervoussysteminvolvingacystoracavityfilled temporalregionsareassociatedwithpsychosis[4-6].
withcerebrospinalfluid,inthebrain’sparenchyma.Itis
caused by either local damage from ischemia in the CasePresentation
brainhemisphere,ormostcommonly,hemorrhageafter A 25-year-old woman presented at the emergency
birth. It can also occurs asaconsequence ofabnormal departmentofthe2nd PsychiatryDepartmentinAttikon
developmentbeforebirth(thesearelesscommoncases) University General Hospital with psychotic
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