Population Hemoglobin Mean and Anemia Prevalence in Papua New Guinea New Metrics for Defining Malaria Endemicity 英文参考文献.docVIP
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Population Hemoglobin Mean and Anemia Prevalence in Papua New Guinea New Metrics for Defining Malaria Endemicity 英文参考文献
PopulationHemoglobinMeanandAnemiaPrevalencein
PapuaNewGuinea:NewMetricsforDefiningMalaria
Endemicity?
NicolasSenn1,2,3*,SeriMaraga1,AlbertSie1,StephenJ.Rogerson2,JohnC.Reeder4,PeterSiba1 ,Ivo
Mueller1
1PapuaNewGuineaInstituteofMedicalResearch,Goroka,PapuaNewGuinea,2DepartmentofMedicine,UniversityofMelbourne,Melbourne,Australia,3SwissTropical
Institute,Basel,Switzerland,4BurnetInstitute,Melbourne,Australia
Abstract
Background:Thehypothesisisthathemoglobin-basedmetricsareusefultoolsforestimatingmalariaendemicityandfor
monitoring malaria control strategies. The aim of this study is to compare population hemoglobin mean and anemia
prevalencetoestablishedindicatorsofmalariaendemicity,includingparasiterates,ratesofenlargedspleensinchildren,
andrecordsof(presumptive)malariadiagnosisamongpopulationslivingwithdifferentlevelsofmalariatransmission.
Methodology/Principal Findings: Convenience sample, multisite cross-sectional household surveys conducted in Papua
NewGuinea.Correlations(r2)betweenpopulationHbmeanandanemiaprevalenceandaltitude,parasiterate,andspleen
ratewereinvestigatedinchildrenages2to10years,andinthegeneralpopulation;21,664individualsfrom156different
communitiesweresurveyed.Altituderangedfrom5to2120meters.Inyoungchildren,correlationsbetweenaltitudeand
parasite rate, population Hb mean, anemia prevalence, and spleen rate were high (r2: 20.77, 0.73, 20.81, and 20.68;
p,0.001).Inthegeneralpopulation,correlationsbetweenaltitudeandpopulationHbmeanandanemiaprevalencewere
0.83and0.85,respectively.Amongyoungchildren,parasiteratecorrelatedhighlywithanemiaprevalence,populationHb
mean, and spleen rate (r2: 0.81, 20.81, and 0.86; p,0.001). Population Hb mean (corrected for direct altitude effects)
increasedwithaltitude,from10.5g/dlat,500mto12.8g/dlat.1500m(p,0.001).
Conclusions/Significance: In PNG, where Plasmodium vivax accounts for an important part of all malaria infections,
population hemoglobin mean and anemia prevalence correlate well with altitude, parasite, and s
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