Poor Decision Making Is a Consequence of Cognitive Decline among Older Persons without Alzheimer’s Disease or Mild Cognitive Impairment 英文参考文献.docVIP
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Poor Decision Making Is a Consequence of Cognitive Decline among Older Persons without Alzheimer’s Disease or Mild Cognitive Impairment 英文参考文献
PoorDecisionMakingIsaConsequenceofCognitive
DeclineamongOlderPersonswithoutAlzheimer’s
DiseaseorMildCognitiveImpairment
PatriciaA.Boyle1,2*,LeiYu1,3,RobertS.Wilson1,3,KeithGamble1,4,AronS.Buchman1,3
,
DavidA.Bennett1,3
1Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America, 2Department of Behavioral Sciences, Rush University
Medical Center, Chicago, Illinois, United States of America, 3Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of
America,4DepartmentofFinance,DePaulUniversity,Chicago,Illinois,UnitedStatesofAmerica
Abstract
Objective:Decisionmakingisanimportantdeterminantofhealthandwell-beingacrossthelifespanbutiscriticalinaging,
when many influential decisions are made just as cognitive function declines. Increasing evidence suggests that older
adults,eventhosewithoutdementia,oftenmakepoordecisionsandareselectivelyvulnerabletoscams.Todate,however,
the factors associated with poor decision making in old age are unknown. The objective of this study was to test the
hypothesis that poor decision making is a consequence of cognitive decline among older persons without Alzheimer’s
diseaseormildcognitiveimpairment.
Methods: Participants were 420 non-demented persons from the Memory and Aging Project, a longitudinal, clinical-
pathologic cohort study of aging in the Chicago metropolitan area. All underwent repeated cognitive evaluations and
subsequentlycompletedassessmentsofdecisionmakingandsusceptibilitytoscams.Decisionmakingwasmeasuredusing
12itemsfromapreviouslyestablishedperformance-basedmeasureandaself-reportmeasureofsusceptibilitytoscams.
Results: Cognitive function data were collected over an average of 5.5years prior to the decision making assessment.
Regressionanalyseswereusedtoexaminewhetherthepriorrateofcognitivedeclinepredictedthelevelofdecisionmaking
andsusceptibilitytoscams;analysescontrolledforage,sex,education,andstartinglevelofcognition.Among4
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