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Polyphenols and Human Health Prevention of Disease and Mechanisms of Action 英文参考文献
Nutrients 2010, 2, 1106-1131; doi:10.3390/nu2111106
OPEN ACCESS
nutrients
ISSN 2072-6643
/journal/nutrients
Review
Polyphenols and Human Health: Prevention of Disease and
Mechanisms of Action
David Vauzour, Ana Rodriguez-Mateos, Giulia Corona, Maria Jose Oruna-Concha and
Jeremy P. E. Spencer *
Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry,
Food and Pharmacy, The University of Reading, PO Box 226, Reading RG6 6AP, UK;
E-Mails: d.vauzour@reading.ac.uk (D.V.); a.m.rodriguezmateos@reading.ac.uk (A.R.-M.);
g.corona@reading.ac.uk (G.C.); m.j.oruna-concha@reading.ac.uk (M.J.O.-C.)
* Author to whom correspondence should be addressed; E-Mail: j.p.e.spencer@reading.ac.uk;
Tel.: +44-0-118-378-8724; Fax: +44-0-118-931-0080.
Received: 25 September 2010; in revised form: 25 October 2010 / Accepted: 1 November 2010 /
Published: 8 November 2010
Abstract: Polyphenols are found ubiquitously in plants and their regular consumption has
been associated with a reduced risk of a number of chronic diseases, including cancer,
cardiovascular disease (CVD) and neurodegenerative disorders. Rather than exerting direct
antioxidant effects, the mechanisms by which polyphenols express these beneficial
properties appear to involve their interaction with cellular signaling pathways and related
machinery that mediate cell function under both normal and pathological conditions. We
illustrate that their interactions with two such pathways, the MAP kinase (ERK, JNK, p38)
and PI3 kinase/Akt signaling cascades, allow them to impact upon normal and abnormal
cell function, thus influencing the cellular processes involved in the initiation and
progression of cancer, CVD and neurodegeneration. For example, their ability to activate
ERK in neurons leads to a promotion of neuronal survival and cognitive enhancements,
both of which influence the progression of Alzheimer’s disease, whilst ERK
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