Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder 英文参考文献.docVIP

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Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder 英文参考文献.doc

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Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder 英文参考文献

Parketal.BehavioralandBrainFunctions2012,8:22 /content/8/1/22 RESEARCH OpenAccess Possibleeffectofnorepinephrinetransporter polymorphismsonmethylphenidate-induced changesinneuropsychologicalfunctionin attention-deficithyperactivitydisorder SubinPark1,Jae-WonKim1,Young-HuiYang2,Soon-BeomHong1,Min-HyeonPark1,Boong-NyunKim1, Min-SupShin1,Hee-JeongYoo3andSoo-ChurlCho1,4* Abstract Background:Dysregulationofnoradrenergicsystemmayplayimportantrolesinpathophysiologyof attention-deficit/hyperactivitydisorder(ADHD).Weexaminedtherelationshipbetweenpolymorphismsinthe norepinephrinetransporterSLC6A2geneandattentionalperformancebeforeandaftermedicationinchildren withADHD. Methods:Fifty-threemedication-na?vechildrenwithADHDweregenotypedandevaluatedusingthecontinuous performancetest(CPT).After8-weeksofmethylphenidatetreatment,thesechildrenwereevaluatedbyCPTagain. WecomparedthebaselineCPTmeasuresandthepost-treatmentchangesintheCPTmeasuresbasedonthe G1287AandtheA-3081TpolymorphismsofSLC6A2. Results:TherewasnosignificantdifferenceinthebaselineCPTmeasuresassociatedwiththeG1287AorA-3081T polymorphisms.Aftermedication,however,ADHDsubjectswiththeG/GgenotypeattheG1287Apolymorphism showedagreaterdecreaseinthemeanomissionerrorscores(p=0.006)thansubjectswiththeG/AorA/A genotypes,andsubjectswiththeTalleleattheA-3081Tpolymorphism(T/TorA/T)showedagreaterdecreasein themeancommissionerrorscores(p=0.003)thanthosewiththeA/Agenotypes. Conclusions:OurresultsprovideevidenceforthepossibleroleoftheG1287AandA-3081TgenotypesofSLC6A2in methylphenidate-inducedimprovementinattentionalperformanceandsupportthenoradrenergichypothesisfor thepathophysiologyofADHD. Keywords:SLC6A2,Polymorphism,Continuousperformancetest,Methylphenidate Background Although the aetiology of ADHD is not fully under- Attention-deficit hyperactivity disorder (ADHD) is a dis- stood,thereisevidencethatdysregulationofthecentral order primarily characterised by inattention, impulsivity, noradrenergicsystemandthedopaminergicsystemmay andhyp