Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder 英文参考文献.docVIP
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Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder 英文参考文献
Parketal.BehavioralandBrainFunctions2012,8:22
/content/8/1/22
RESEARCH
OpenAccess
Possibleeffectofnorepinephrinetransporter
polymorphismsonmethylphenidate-induced
changesinneuropsychologicalfunctionin
attention-deficithyperactivitydisorder
SubinPark1,Jae-WonKim1,Young-HuiYang2,Soon-BeomHong1,Min-HyeonPark1,Boong-NyunKim1,
Min-SupShin1,Hee-JeongYoo3andSoo-ChurlCho1,4*
Abstract
Background:Dysregulationofnoradrenergicsystemmayplayimportantrolesinpathophysiologyof
attention-deficit/hyperactivitydisorder(ADHD).Weexaminedtherelationshipbetweenpolymorphismsinthe
norepinephrinetransporterSLC6A2geneandattentionalperformancebeforeandaftermedicationinchildren
withADHD.
Methods:Fifty-threemedication-na?vechildrenwithADHDweregenotypedandevaluatedusingthecontinuous
performancetest(CPT).After8-weeksofmethylphenidatetreatment,thesechildrenwereevaluatedbyCPTagain.
WecomparedthebaselineCPTmeasuresandthepost-treatmentchangesintheCPTmeasuresbasedonthe
G1287AandtheA-3081TpolymorphismsofSLC6A2.
Results:TherewasnosignificantdifferenceinthebaselineCPTmeasuresassociatedwiththeG1287AorA-3081T
polymorphisms.Aftermedication,however,ADHDsubjectswiththeG/GgenotypeattheG1287Apolymorphism
showedagreaterdecreaseinthemeanomissionerrorscores(p=0.006)thansubjectswiththeG/AorA/A
genotypes,andsubjectswiththeTalleleattheA-3081Tpolymorphism(T/TorA/T)showedagreaterdecreasein
themeancommissionerrorscores(p=0.003)thanthosewiththeA/Agenotypes.
Conclusions:OurresultsprovideevidenceforthepossibleroleoftheG1287AandA-3081TgenotypesofSLC6A2in
methylphenidate-inducedimprovementinattentionalperformanceandsupportthenoradrenergichypothesisfor
thepathophysiologyofADHD.
Keywords:SLC6A2,Polymorphism,Continuousperformancetest,Methylphenidate
Background
Although the aetiology of ADHD is not fully under-
Attention-deficit hyperactivity disorder (ADHD) is a dis- stood,thereisevidencethatdysregulationofthecentral
order primarily characterised by inattention, impulsivity, noradrenergicsystemandthedopaminergicsystemmay
andhyp
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