Prediction of Cardiovascular Events by Using Non-Vascular Findings on Routine Chest CT 英文参考文献.docVIP

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Prediction of Cardiovascular Events by Using Non-Vascular Findings on Routine Chest CT 英文参考文献.doc

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Prediction of Cardiovascular Events by Using Non-Vascular Findings on Routine Chest CT 英文参考文献

PredictionofCardiovascularEventsbyUsing Non-VascularFindingsonRoutineChestCT PimA.deJong1*,MartijnJ.A.Gondrie2,ConstantinusF.M.Buckens2,PeterC.Jacobs1,WillemP.Th.M. Mali1,YolandavanderGraaf2,thePROVIDIstudygroup¤ 1DepartmentofRadiology,UniversityMedicalCenterUtrecht,Utrecht,TheNetherlands,2JuliusCenterforHealthSciencesandPrimaryCare,UniversityMedicalCenter Utrecht,Utrecht,TheNetherlands Abstract Background: Routine computed tomography (CT) examinations contain an abundance of findings unrelated to the diagnostic question. Those with prognostic significance may contribute to early detection and treatment of disease, irrelevantfindingscanbeignored.WeaimedtoassesstheassociationbetweenunrequestedchestCTfindingsinlungs, mediastinumandpleuraandfuturecardiovascularevents. Methods: Multi-center case-cohort study in 5 tertiary and 3 secondary care hospitals involving 10410 subjects who underwent routine chest CT for non-cardiovascular reasons. 493 cardiovascular hospitalizations or deaths were recorded duringanaveragefollow-uptimeof17.8months.1191patientswererandomlysampledtoserveasacontrolsubcohort. Hazardratiosandannualizedeventrateswerecalculated. Results:Abnormalitiesinthelung(26–44%),pleura(14–15%)andmediastinum(20%)werecommon.Hazardratiosafter adjustment for age and sex were for airway wall thickening 2.26 (1.59–3.22), ground glass opacities 2.50 (1.72–3.62), consolidations1.97(1.12–3.47),pleuraleffusions2.77(1.81–4.25)andlymph-nodes2.04(1.40–2.96).Correspondingannual eventrateswere5.5%,6.0%,3.8%,10.2%and4.4%. Conclusions: We have identified several common chest CT findings that are predictive for future risk of cardiovascular eventsandfoundthatotherfindingshavelittleutilityforthis.Theaddedvalueofthenon-vascularpredictorstoestablished vascularcalcificationsonCTremainstobedetermined. Citation:deJongPA,GondrieMJA,BuckensCFM,JacobsPC,MaliWPThM,etal.(2011)PredictionofCardiovascularEventsbyUsingNon-VascularFindingson RoutineChestCT.PLoSONE6(10):e26036.doi:10.1371/journal.