Predicting Protein Phenotypes Based on Protein-Protein Interaction Network 英文参考文献.docVIP

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Predicting Protein Phenotypes Based on Protein-Protein Interaction Network 英文参考文献.doc

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Predicting Protein Phenotypes Based on Protein-Protein Interaction Network 英文参考文献

PredictingProteinPhenotypesBasedonProtein-Protein InteractionNetwork LeleHu1,2.,TaoHuang3,4.,Xiao-JunLiu5*,Yu-DongCai1,6* 1Institute of Systems Biology, Shanghai University, Shanghai, China, 2Department of Chemistry, College of Sciences, Shanghai University, Shanghai, China, 3Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, 4Shanghai Center for Bioinformation Technology,Shanghai,China,5CollegeofAnimalScienceandTechnology,ShiheziUniversity,ShiheziCity,Xinjiang,China,6CentreforComputationalSystemsBiology, FudanUniversity,Shanghai,China Abstract Background:Identifyingassociatedphenotypesofproteinsisachallengeofthemoderngeneticssincethemultifactorial trait often results from contributions of many proteins. Besides the high-through phenotype assays, the computational methodsarealternativewaystoidentifythephenotypesofproteins. Methodology/PrincipalFindings:Here,weproposedanewmethodforpredictingproteinphenotypesinyeastbasedon protein-proteininteractionnetwork.Insteadofonlythemostlikelyphenotype,aseriesofpossiblephenotypesforthequery proteinweregeneratedandrankedacordingtothetetheringpotentialscore.Asaresult,thefirstorderpredictionaccuracy ofourmethodachieved65.4%evaluatedbyJackknifetestof1,267proteinsinbuddingyeast,muchhigherthanthesuccess rate(15.4%)ofarandomguess.Andthelikelihoodofthefirst3predictedphenotypesincludingalltherealphenotypesof theproteinswas70.6%. Conclusions/Significance: The candidate phenotypes predicted by our method provided useful clues for the further validation. In addition, the method can be easily applied to the prediction of protein associated phenotypes in other organisms. Citation:HuL,HuangT,LiuX-J,CaiY-D(2011)PredictingProteinPhenotypesBasedonProtein-ProteinInteractionNetwork.PLoSONE6(3):e17668.doi:10.1371/ journal.pone.0017668 Editor:HitoshiOkazawa,TokyoMedicalandDentalUniversity,Japan ReceivedSeptember7,2010;AcceptedFebruary10,2011;PublishedMarch10,2011 Copyright:?