Predicting Secretory Proteins of Malaria Parasite by Incorporating Sequence Evolution Information into Pseudo Amino Acid Composition via Grey System Model 英文参考文献.docVIP

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Predicting Secretory Proteins of Malaria Parasite by Incorporating Sequence Evolution Information into Pseudo Amino Acid Composition via Grey System Model 英文参考文献.doc

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Predicting Secretory Proteins of Malaria Parasite by Incorporating Sequence Evolution Information into Pseudo Amino Acid Composition via Grey System Model 英文参考文献

PredictingSecretoryProteinsofMalariaParasiteby IncorporatingSequenceEvolutionInformationinto PseudoAminoAcidCompositionviaGreySystemModel Wei-ZhongLin1,2,Jian-AnFang1,XuanXiao2,3*,Kuo-ChenChou3* 1Information Science and technology School, Donghua University, Shanghai, China, 2Computer Department, Jing-De-Zhen Ceramic Institute, Jing-De-Zhen, China, 3GordonLifeScienceInstitute,SanDiego,California,UnitedStatesofAmerica Abstract Themalariadiseasehasbecomeacauseofpovertyandamajorhindrancetoeconomicdevelopment.Theculpritofthe disease is the parasite, which secretes an array of proteins within the host erythrocyte to facilitate its own survival. Accordingly, the secretory proteins of malaria parasite have become a logical target for drug design against malaria. Unfortunately,withtheincreasingresistancetothedrugsthusdeveloped,thesituationhasbecomemorecomplicated.To copewiththedrugresistanceproblem,onestrategyistotimelyidentifythesecretedproteinsbymalariaparasite,which canserveaspotentialdrugtargets.However,itisbothexpensiveandtime-consumingtoidentifythesecretoryproteinsof malaria parasite by experiments alone. To expedite the process for developing effective drugs against malaria, a computationalpredictorcalled‘‘iSMP-Grey’’wasdevelopedthatcanbeusedtoidentifythesecretoryproteinsofmalaria parasitebasedontheproteinsequenceinformationalone.Duringthepredictionprocessaproteinsamplewasformulated witha60D(dimensional)featurevectorformedbyincorporatingthesequenceevolutioninformationintothegeneralform ofPseAAC(pseudoaminoacidcomposition)viaagreysystemmodel,whichisparticularlyusefulforsolvingcomplicated problemsthatarelackofsufficientinformationorneedtoprocessuncertaininformation.Itwasobservedbythejackknife testthatiSMP-Greyachievedanoverallsuccessrateof94.8%,remarkablyhigherthanthosebytheexistingpredictorsin thisarea.Asauser-friendlyweb-server,iSMP-Greyisfreelyaccessibletothepublicat/iSMP-Grey. Moreover,fortheconvenienceofmostexperimentalscientists,astep-by-stepguideisprovidedonho