Predicting effects of blood flow rate and size of vessels in a vasculature on hyperthermia treatments using computer simulation 英文参考文献.docVIP

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Predicting effects of blood flow rate and size of vessels in a vasculature on hyperthermia treatments using computer simulation 英文参考文献.doc

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Predicting effects of blood flow rate and size of vessels in a vasculature on hyperthermia treatments using computer simulation 英文参考文献

Huangetal.BioMedicalEngineeringOnLine2010,9:18 /content/9/1/18 RESEARCH OpenAccess Predictingeffectsofbloodflowrateandsizeof vesselsinavasculatureonhyperthermia treatmentsusingcomputersimulation Huang-WenHuang1*,Tzu-ChingShih2,Chihng-TsungLiauh3 *Correspondence:hhw402@mail. Abstract .tw 1DepartmentofInnovative InformationandTechnology, SoftwareEngineeringGroup, Background:PennesBioHeatTransferEquation(PBHTE)hasbeenwidelyusedto approximatetheoveralltemperaturedistributionintissueusingaperfusion LangyangCampus,Tamkang University,I-lanCounty26247, Taiwan parametertermintheequationduringhyperthermiatreatment.Inthesimilar modeling,effectivethermalconductivity(Keff)modelusesthermalconductivityasa parametertopredicttemperatures.Howevertheequationsdonotdescribethe thermalcontributionofbloodvessels.Acountercurrentvascularnetworkmodel whichrepresentsamorefundamentalapproachtomodelingtemperaturesintissue thandothegenerallyusedapproximateequationssuchasthePennesBHTEor effectivethermalconductivityequationswaspresentedin1996.Thistypeofmodelis capableofcalculatingthebloodtemperatureinvesselsanddescribingavasculature inthetissueregions. Methods:Inthispaper,acountercurrentbloodvesselnetwork(CBVN)modelfor calculatingtissuetemperatureshasbeendevelopedforstudyinghyperthermiacancer treatment.Weuseasystematicapproachtorevealtheimpactofavasculatureofblood vesselsagainstasinglevesselwhichmoststudieshavepresented.Avasculatureillustrates branchingvesselsattheperipheryofthetumorvolume.Thegeneraltrendspresentin thisvascularmodelaresimilartothoseshownforphysiologicalsystemsinGreenand Whitmore.The3-Dtemperaturedistributionsareobtainedbysolvingtheconduction equationinthetissueandtheconvectiveenergyequationwithspecifiedNusseltnumber inthevessels. Results:ThispaperinvestigateseffectsofsizeofbloodvesselsintheCBVNmodel ontotalabsorbedpowerinthetreatedregionandbloodflowrates(orperfusion rate)intheCBVNontemperaturedistributionsduringhyperthermiacancer treatment.Also,thesameoptimizedpowerdistributiond