Predicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multi-Parametric MRI in Patients with Stroke 英文参考文献.docVIP

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Predicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multi-Parametric MRI in Patients with Stroke 英文参考文献.doc

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Predicting Final Extent of Ischemic Infarction Using Artificial Neural Network Analysis of Multi-Parametric MRI in Patients with Stroke 英文参考文献

PredictingFinalExtentofIschemicInfarctionUsing ArtificialNeuralNetworkAnalysisofMulti-Parametric MRIinPatientswithStroke HassanBagher-Ebadian1,2*,KouroshJafari-Khouzani3,PanayiotisD.Mitsias1,MeiLu4,HamidSoltanian- Zadeh3,5,MichaelChopp1,2,JamesR.Ewing1,2,6,7 1DepartmentofNeurology,HenryFordHospital,Detroit,Michigan,UnitedStatesofAmerica,2DepartmentofPhysics,OaklandUniversity,Rochester,Michigan,United StatesofAmerica,3DepartmentofDiagnosticRadiology,HenryFordHospital,Detroit,Michigan,UnitedStatesofAmerica,4DepartmentofBiostatisticsandResearch Epidemiology,HenryFordHospital,Detroit,Michigan,UnitedStatesofAmerica,5ControlandIntelligentProcessingCenterofExcellence(CIPCE),SchoolofElectricaland ComputerEngineering,UniversityofTehran,Tehran,Iran,6DepartmentofPhysiology,WayneStateUniversity,Detroit,Michigan,UnitedStatesofAmerica,7Department ofNeurology,WayneStateUniversity,Detroit,Michigan,UnitedStatesofAmerica Abstract Inhemispheric ischemic stroke, thefinal size of theischemic lesion is the mostimportant correlate of clinical functional outcome. Using a set of acute-phase MR images (Diffusion-weighted - DWI, T1-weighted – T1WI, T2-weighted-T2WI, and protondensityweighted-PDWI)forinputs,andthechronicT2WIat3monthsasanoutcomemeasure,anArtificialNeural Network(ANN)wastrainedtopredictthe3-monthoutcomeintheformofavoxel-by-voxelforecastofthechronicT2WI. TheANNwastrainedandtestedusing12subjects(with83slicesand140218voxels)usingaleave-one-outcross-validation method with calculation of the Area Under the Receiver Operator Characteristic Curve (AUROC) for training, testing and optimizationoftheANN.Aftertrainingandoptimization,theANNproducedmapsofpredictedoutcomethatwerewell correlated(r=0.80,p,0.0001)withtheT2WIat3monthsforall12patients.ThisresultimpliesthatthetrainedANNcan provideanestimateof3-monthischemiclesiononT2WIinastableandaccuratemanner(AUROC=0.89). Citation:Bagher-EbadianH,Jafari-KhouzaniK,MitsiasPD,LuM,Soltanian-ZadehH,etal.(2011)PredictingFinalExtentofIschemicInfarctio