Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis 英文参考文献.docVIP

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Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis 英文参考文献.doc

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Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis 英文参考文献

PredictingInVivoAnti-HepatofibroticDrugEfficacy BasedonInVitroHigh-ContentAnalysis BaixueZheng1,2,3,LoolingTan2,XuejunMo2,6,WeimiaoYu9,11,YanWang2,10,LisaTucker-Kellogg1,3 , RoyE.Welsch1,13,PeterT.C.So1,4,12,HanryYu1,2,3,4,5,7,8,12 * 1Computation and Systems Biology Program, Singapore-MIT Alliance, National University of Singapore, Singapore, Singapore, 2Institute of Bioengineering and Nanotechnology, A*STAR, Singapore, Singapore, 3Mechanobiology Institute, National University of Singapore, Singapore, Singapore, 4Singapore-MIT Alliance for ResearchandTechnology, BioSyM,Singapore, Singapore, 5Department ofPhysiology,YongLooLinSchoolofMedicine,NationalUniversityofSingapore, Singapore, Singapore, 6Department of Chemistry, Faculty of Science, National University of Singapore, Singapore, Singapore, 7NUS Graduate School for Integrative Sciences, National University of Singapore, Singapore, Singapore, 8NUS Tissue-Engineering Programme, National University of Singapore, Singapore, Singapore, 9Imaging Informatics Division, Bioinformatics Institute, A*STAR, Singapore, Singapore, 10Department of Hepatobiliary Surgery, Southern Medical University Affiliated Zhujiang Hospital,Guangzhou,China,11CentralImagingFacility,InstituteofMolecularandCellBiology,A*STAR,Singapore,Singapore,12DepartmentofMechanicalEngineering andBiologicalEngineering,MassachusettsInstituteofTechnology,Cambridge,Massachusetts,UnitedStatesofAmerica,13EngineeringSystemsDivision,SloanSchoolof Management,MassachusettsInstituteofTechnology,Cambridge,Massachusetts,UnitedStatesofAmerica Abstract Background/Aims:Manyanti-fibroticdrugswithhighinvitroefficaciesfailtoproducesignificanteffectsinvivo.Theaimof thisworkistouseastatisticalapproachtodesignanumericalpredictorthatcorrelatesbetterwithinvivooutcomes. Methods:High-contentanalysis(HCA)wasperformedwith49drugsonhepaticstellatecells(HSCs)LX-2stainedwith10 fibroticmarkers.,0.3billionfeaturevaluesfromallcellsin.150,000imageswerequantifiedtoreflectthedrugeffects.