Prediction of IBD based on population history for fine gene mapping 英文参考文献.docVIP

下载本文档

9
0
约4.36万字
约 22页
2017-05-12 发布于上海
举报
版权申诉

Prediction of IBD based on population history for fine gene mapping 英文参考文献.doc

1、本文档共22页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Prediction of IBD based on population history for fine gene mapping 英文参考文献

Genet.Sel.Evol.38(2006)231–252 c INRA,EDPSciences,2006 DOI:10.1051/gse:2006001 231 Originalarticle PredictionofIBDbasedonpopulation historyfor?negenemapping JulesH????????-S??????′ ?,ChrisS.H????, ′ JohnA.W???????? RoslinInstitute,Midlothian,EH259PS,Scotland,UK (Received31March2005;accepted19December2005) Abstract – A novel multiple regression method (RM) is developed to predict identity-by- descent probabilities at a locus L (IBDL), among individuals without pedigree, given infor- mationonsurroundingmarkersandpopulationhistory.TheseIBDLprobabilitiesareafunction of theincreaseinlinkagedisequilibrium(LD)generated bydrift inahomogeneous popula- tionovergenerations.Threeparametersaresu?cienttodescribepopulationhistory:e?ective populationsize(Ne),numberofgenerationssincefoundation(T),andmarkerallelefrequen- ciesamongfounders(p).IBDLareusedinasimulationstudytomapaquantitativetraitlocus (QTL)viavariancecomponent estimation.RMiscomparedtoacoalescentmethod(CM)in termsofpowerandrobustnessofQTLdetection.Di?erencesbetweenRMandCMaresmall butsigni?cant.Forexample,RMismorepowerfulthanCMindioeciouspopulations,butnot inmonoecious populations.Moreover,RMismorerobustthanCMwhenmarkerphasesare unknownorwhenthereiscompleteLDamongfoundersorNeiswrong,andlessrobustwhen piswrong. CM utilisesall marker haplotype information, whereas RM utilisesinformation containedineachindividualmarkerandallpossiblemarkerpairsbutnotinhigherorderinter- actions.RMconsistsofafamilyofmodelsencompassingfourdi?erentpopulationstructures, andtwowaysof usingmarker information,whichcontrastswiththesinglemodel thatmust caterforallpossibleevolutionaryscenariosinCM. QTL?nemapping/identity-by-descent 1. INTRODUCTION Theconcept ofgeneticrelationship playsakeyroleinmanyareasofge- netic research. Genetic relationships have been traditionally estimated from pedigrees, andalsorecentlyfrommarkerinformation. Thus,ifapedigreeis notavailable,relationshipscanstillbeinferredfrommarkerdataalone.Some methodsuseu