Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort 英文参考文献.docVIP
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Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort 英文参考文献
Leungetal.BMCPregnancyandChildbirth2013,13:2
/1471-2393/13/2
RESEARCH ARTICLE
OpenAccess
Prenatalmicronutrientsupplementationand
postpartumdepressivesymptomsinapregnancy
cohort
BrendaMYLeung1,BonnieJKaplan1,2*,CatherineJField3,SuzanneTough1,2,MishaEliasziw1,4,
MarielFajerGomez3,LindaJMcCargar3,LisaGagnon5andtheAPrONStudyTeam
Abstract
Background:Postpartumdepressionisaseriousproblemforwomenandtheiroffspring.Micronutrient
supplementsarerecommendedforpregnantwomenbecauseoftheirdocumentedprotectiveeffectsforthe
offspring,buttheirpotentialbeneficialeffectsonmaternalmentalhealthareunknown.Thisstudyinvestigatedthe
associationbetweenprenatalmicronutrientsupplementationandtheriskforsymptomsofpostpartumdepression
inalongitudinalpregnancycohortfromtheAlbertaPregnancyOutcomesandNutrition(APrON)study.
Methods:Participantscamefromacohortofthefirst600APrONwomen.Supplementalnutrientintakeand
symptomsofdepression(measuredwiththeEdinburghPostnatalDepressionScale(EPDS))werecollectedateach
trimesterand12weekspostpartum.
Results:Ofthe475participantswhocompletedtheEPDSatleasttwiceinpregnancyandat12weekspostpartum,
416(88%)scored10and59(12%)scored≥10,whereanEPDS≥10isconsideredtobe“atleastprobableminor
depression”.MeannutrientintakesfromsupplementswerehigherinwomenwithlowerEPDSscores,particularly
selenium(p=0.0015)andomega-3s(p=0.01).Bivariateanalysesshowedthatseveraldemographicandsocial/
lifestylevariableswereassociatedwithEPDS≥10:nothavingbeenborninCanada(p=0.01),greaternumberof
chronicconditions(p=0.05),greaternumberofstressfullifeeventsduringthispregnancy(p=0.02),andlower
prenatalandpostnatalsupport(p=0.0043andp=0.0001,respectively).Adjustingforcovariatesandnutrients
knowntobeassociatedwithpostpartumdepression,logisticregressionshowedthathavingaprenatalEPDS≥10
increasedtheoddsofpostpartumdepressivesymptoms(secondandthirdtrimesterOR=3.29,95%CI=1.55-
7.01,p=0.004andOR=4.26,95%CI=2.05-8.85,p0.0001,respectively),whileprenatalsupplementalselenium
(per10mcg,OR=0.76,95%CI=0.74-0.78,p=0.001
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