Preparation and properties of the specific anti-influenza virus transfer factor 英文参考文献.docVIP

Lietal.HeadFaceMedicine2010,6:22 /content/6/1/22 HEAD FACE MEDICINE METHODOLOGY OpenAccess Preparationandpropertiesofthespecific anti-influenzavirustransferfactor ChongbiLi*,LihuaHuang,YanpingWang,XiangleLi,ShaoweiLiang,YingnaZheng Abstract Specificanti-influenzavirusandnormaltransferfactorspreparedinanexperimentalanimalmodel,thepig,have beentestedfortheircomponents,characteristics,andactivityofknownspecificity.Twotransferfactorsaresmall molecularmixturewhichconsistentirelyorpartlyofpolypeptidesandpolynucleosides.Moreover,thebiological activityoftransferfactorscouldbeapprovedbyRosettestestandspecificskintest.Thestudywouldlayafounda- tionfortheresearchanddevelopmentofotherspecifictransferfactor. Introduction thatitcanbeutilizedforprevention,transferringimmu- Transfer Factor (TF) wasdiscovered inthe 1940’sand nity prior to infection. Because it is derived from lym- hasbeenextensivelystudiedforthepast50years(1).In phocytes of immune donors, it has the potential to recentyears,ithasbeenknownthatTransferFactorcan answer the challenge of unknown or ill-defined patho- transfercell-mediatedimmunity(CMI)fromanimmune gens [4]. Thus, it is important that a specific TF to a donoranimaltoanon-immunerecipient.Andnowitis new antigen can be made swiftly and used for preven- notonly ascientifically recognized delivery system for tion as well as for the treatment of infected patients. transferringimmunesystemadvantagesfromonespecies Such as influenza viruses infection presents a threat of toanotherbutalsomosteffectiveinregulatingimmunity producingapandemicThisisofgreatconcern,sinceno toinfections inwhichcell-mediated immunity(CMI;T effective vaccine isavailable orcanbemadebefore the cells)isimportantforcontrollingtheinfection[1].Ithas occurrenceoftheevent. been studied in various types of infections including We present arguments for the use of cell mediated viruses,bacteria,andfungalorganisms.Therefore,Many immunity for thepreventi