Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation A Single Arm Trial 英文参考文献.docVIP

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Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation A Single Arm Trial 英文参考文献.doc

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Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation A Single Arm Trial 英文参考文献

PreliminaryEvidenceforCellMembraneAmeliorationin ChildrenwithCysticFibrosisby5-MTHFandVitaminB12 Supplementation:ASingleArmTrial CinziaScambi1*,LuciaDeFranceschi1,PatriziaGuarini1,FabioPoli1,AngelaSiciliano1,PatriziaPattini1, AndreaBiondani1,ValentinaLaVerde1,OscarBortolami2,FrancescoTurrini3,FrancoCarta4 ,Ciro D’Orazio5,BaroukhM.Assael5,GiovanniFaccini6,LisaM.Bambara1 1DepartmentofClinicalandExperimentalMedicine,SectionofRheumatologyInternalMedicine,UniversityofVerona,Verona,Italy,2DepartmentofMedicineand Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy, 3Department of Genetic, Biological and Medical Chemistry, Section of MedicalChemistry,UniversityofTorino,Torino,Italy,4Nurex,Sassari,Italy,5CenterforCysticFibrosisCare,HospitalofVerona,Verona,Italy,6DepartmentofBiomedical andMorphologicalScience,SectionofClinicalChemistry,UniversityofVerona,Verona,Italy Abstract Background:Cysticfibrosis(CF)isoneofthemostcommonfatalautosomalrecessivedisordersintheCaucasianpopulation caused by mutations of gene for the cystic fibrosis transmembrane conductance regulator (CFTR). New experimental therapeutic strategies for CF propose a diet supplementation to affect the plasma membrane fluidity and to modulate amplifiedinflammatoryresponse.Theobjectiveofthisstudywastoevaluatetheefficacyof5-methyltetrahydrofolate(5- MTHF)andvitaminB12supplementationforamelioratingcellplasmamembranefeaturesinpediatricpatientswithcystic fibrosis. MethodologyandPrincipalFindings:AsinglearmtrialwasconductedfromApril2004toMarch2006inanItalianCFcare centre.31childrenwithCFagedfrom3to8yearsoldwereenrolled.Exclusioncriteriawerediabetes,chronicinfectionsof theairwaysandregularantibioticsintake.ChildrenwithCFweresupplementedfor24weekswith5-methyltetrahydrofolate (5-MTHF,7.5mg/day)andvitaminB12(0.5mg/day).Redbloodcells(RBCs)wereusedtoinvestigateplasmamembrane, since RBCs share lipid, protein composition and organization with other cell types. We evaluated RBCs membra