Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis 英文参考文献.docVIP

BMC Psychiatry BioMedCentral Research article Open Access Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis Virginia L Stauffer*1, Ilya Lipkovich2, Vicki Poole Hoffmann3, Alexandra N Heinloth4, H Scott McGregor1 and Bruce J Kinon3 Address: 1Neuroscience, Lilly USA, LLC, Indianapolis, IN 46285, USA, 2Statistics, Eli Lilly and Company, IN 46285, USA, 3Neuroscience, Eli Lilly and Company, IN 46285, USA and 4i3Statprobe, subsidiary of United Health Group, Ann Arbor, MI, USA Email: Virginia L Stauffer* - Stauffer_Virginia@L; Ilya Lipkovich - Lipkovich_Ilya_A@L; Vicki Poole Hoffmann - Hoffmann_Vicki_Poole@L; Alexandra N Heinloth - Alexandra.Heinloth@i3S; H Scott McGregor - Mcgregor_Scott_H@L; Bruce J Kinon - Kinon_Bruce@L * Corresponding author Published: 28 March 2009 Received: 20 August 2008 Accepted: 28 March 2009 BMC Psychiatry 2009, 9:12 doi:10.1186/1471-244X-9-12 This article is available from: /1471-244X/9/12 ? 2009 Stauffer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: This study focuses on exploring the relationship between changes in appetite or eating behaviors and subsequent weight change for adult patients with schizophrenia or bipolar disorder treated with olanzapine and adjunctive potential weight mitigating pharmacotherapy. The aim is not to compare different weight mitigating agents, but to evaluate patients characteristics and changes in their eating behaviors during treatment. Identification of patient subgroups with different degrees of susceptibility to the effect of weight mitigating agents during olanzapine treatment may aid clinicians in treatment decisions.