Prediction of trans-antisense transcripts in Arabidopsis thaliana 英文参考文献.docVIP

Open Access Re rch 2006WangetVoal.lumesea7, Issue 10, Article R92 Prediction of trans-antisense transcripts in Arabidopsis thaliana Huan Wang*?, Nam-Hai Chua? and Xiu-Jie Wang* Addresses: *State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. ?Graduate University of the Chinese Academy of Sciences, Beijing 100101, China. ?Laboratory of Plant Molecular Biology, The Rockefeller University, New York, NY 10021, USA. Correspondence: Xiu-Jie Wang. Email: xjwang@ Published: 13 October 2006 Received: 1 August 2006 Revised: 2 October 2006 Accepted: 13 October 2006 Genome Biology 2006, 7:R92 (doi:10.1186/gb-2006-7-10-r92) The electronic version of this article is the complete one and can be found online at /2006/7/10/R92 ? 2006 Wang et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Trans-antisensecopulAd bgeeninovmoelv-wedtranscriptsidien sccormeepnlefxinorreArabidopsistrans-naturalgulatory netwantisenseorks in eutranscriptsk ryotes./inpitArabidopsis thaliana /itsuggests that antisense transcripts Abstract Background: Natural antisense transcripts (NATs) are coding or non-coding RNAs with sequence complementarity to other transcripts (sense transcripts). These RNAs could potentially regulate the expression of their sense partner(s) at either the transcriptional or post- transcriptional level. Experimental and computational methods have demonstrated the widespread occurrence of NATs in eukaryotes. However, most previous studies only focused on cis-NATs with little attention being paid to NATs that originate in trans. Results: We have performed a genome-wide screen of trans-NATs in Arabidops