Predictors of Fatigue Severity in Early Systemic Sclerosis A Prospective Longitudinal Study of the GENISOS Cohort 英文参考文献.docVIP

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Predictors of Fatigue Severity in Early Systemic Sclerosis A Prospective Longitudinal Study of the GENISOS Cohort 英文参考文献.doc

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Predictors of Fatigue Severity in Early Systemic Sclerosis A Prospective Longitudinal Study of the GENISOS Cohort 英文参考文献

PredictorsofFatigueSeverityinEarlySystemicSclerosis: AProspectiveLongitudinalStudyoftheGENISOSCohort ShervinAssassi1*.,AstrudL.Leyva2.,MaureenD.Mayes1,RoozbehSharif1,2,DeepthiK.Nair1 ,Michael Fischbach3,NganNguyen1,JohnD.Reveille1,EmilioB.Gonzalez2,TerryA.McNearney2¤,forthe GENISOSStudyGroup 1DepartmentofMedicine,DivisionofRheumatology,UniversityofTexasHealthScienceCenteratHouston,Houston,Texas,UnitedStatesofAmerica,2Departmentof Medicine,UniversityofTexasMedicalBranchatGalveston,Galveston,Texas,UnitedStatesofAmerica,3DepartmentofMedicine,DivisionofRheumatology,Universityof TexasHealthScienceCenteratSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica Abstract Objectives:LongitudinalstudiesexaminingthebaselinepredictorsoffatigueinSSchavenotbeenreported.Ourobjectives weretoexaminethecourseoffatigueseverityovertimeandtoidentifybaselineclinical,demographic,andpsychosocial predictorsofsequentiallyobtainedfatiguescoresinearlySSc.Wealsoexaminedbaselinepredictorsofchangeinfatigue severityovertime. Methods:Weanalyzed1090longitudinalFatigueSeverityScale(FSS)scoresbelongingto256patientswhowereenrolledin theGeneticsversusEnvironmentinSclerodermaOutcomesStudy(GENISOS).Predictivesignificanceofbaselinevariablesfor sequentiallyobtainedFSSscoreswasexaminedwithgeneralizedlinearmixedmodels.PredictorsofchangeinFSSovertime wereexaminedbyaddinganinteractiontermbetweenthebaselinevariableandtime-in-studytothemodel. Results:Thepatients’meanagewas48.6years,47%wereCaucasians,and59%haddiffusecutaneousinvolvement.The meandiseasedurationatenrollmentwas2.5years.TheFSSwasobtainedatenrollmentandfollow-upvisits(meanfollow- uptime=3.8years).AveragebaselineFSSscorewas4.7(60.96).TheFSSwasrelativelystableanddidnotshowaconsistent trend for change over time (p=0.221). In a multivariable model of objective clinical variables, higher Medsger Gastrointestinal(p=0.006)andJoint(p=0.024)SeverityIndices,andanti-U1-RNPantibodies(p=0.024)wereindependent predictorsofhigherFSS.Inthefinalmodel,ineffectivecopingskil