Preussianone, a New Flavanone-Chromone Biflavonoid from Garcinia preussii Engl. 英文参考文献.docVIP

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Preussianone, a New Flavanone-Chromone Biflavonoid from Garcinia preussii Engl. 英文参考文献.doc

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Preussianone, a New Flavanone-Chromone Biflavonoid from Garcinia preussii Engl. 英文参考文献

Molecules 2012, 17, 6114-6125; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Preussianone, a New Flavanone-Chromone Biflavonoid from Garcinia preussii Engl. Bernadette Biloa Messi 1,2, Karine Ndjoko-Ioset 2,*, Barbara Hertlein-Amslinger 3, Alain Meli Lannang 4, Augustin E. Nkengfack 1, Jean-Luc Wolfender 2, Kurt Hostettmann 2 and Gerhard Bringmann 3,* 1 Department of Organic Chemistry, University of Yaoundé, P.O. Box 812, Yaoundé, Cameroon; E-Mails: biloa83@yahoo.fr (B.B.M.); ankengf@yahoo.fr (A.E.N.) 2 School of Pharmaceutical Sciences, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland; E-Mails: jean-luc.wolfender@unige.ch (J.-L.W.); kurt.hostettman@unige.ch (K.H.) 3 Institute of Organic Chemistry, Am Hubland, University of Würzburg, Würzburg 97074, Germany; E-Mail: hertlein@chemie.uni-wuerzburg.de 4 Department of Chemistry, Higher Teachers’ Training College, University of Maroua, P.O. Box 46, Maroua, Cameroon; E-Mail: alainmeli@ * Authors to whom correspondence should be addressed; E-Mails: karine.ndjoko@unige.ch (K.N.-I.); bringman@chemie.uni-wuerzburg.de (G.B.); Tel.: +41-22-379-3387 (K.N.-I.); Fax: +41-21-379-3399 (K.N.-I.); Tel.: +49-931-318-5323 (G.B.); Fax: +49-931-318-4755 (G.B.). Received: 20 March 2012; in revised form: 26 April 2012 / Accepted: 14 May 2012 / Published: 21 May 2012 Abstract: A new flavanone-chromone biflavonoid, preussianone (1), has been isolated from the leaves of Garcinia preussii, along with four known biflavonoids. The absolute stereostructures were elucidated by chemical, spectroscopic, and chiroptical methods. The biological properties of the new biflavonoid against several bacterial strains were evaluated. Keywords: Garcinia biflavonoids; absolute configuration; high-temperature NMR; antibacterial activity 1. Introduction Although the occurrence of biflavonoids is limited to only a few families, they constitute one of the