Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent 英文参考文献.docVIP

Molecules 2010, 15, 1967-1972; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Preparation of the Pyridinium Salts Differing in the Length of the N-Alkyl Substituent Jan Marek 1,2, Petr Stodulka 1, Jiri Cabal 1, Ondrej Soukup 1, Miroslav Pohanka 1, Jan Korabecny 3, Kamil Musilek 1 and Kamil Kuca 1,* 1 Faculty of Military Health Science, University of Defence, Hradec Kralove, 50001, Czech Republic 2 Vakos XT, Prague, 18600, Czech Republic 3 Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove 50001, Czech Republic * Author to whom correspondence should be addressed; E-Mail: kucakam@pmfhk.cz. Received: 14 December 2009; in revised form: 4 March 2010 / Accepted: 10 March 2010 / Published: 19 March 2010 Abstract: Quaternary pyridinium salts with chains ranging from C8 to C20 belong in the large group of cationic surfactants. In this paper, the preparation of such cationic surface active agents based on the pyridinium moiety and differing in the length of the N-alkyl chain is described. Additionally, HPLC technique was established to distinguish each prepared pyridinium analogue. This study represents universal method for preparation and identification of quaternary pyridinium detergents. Keywords: pyridinium salt; synthesis; micellar catalysts; HPLC; TLC 1. Introduction Cationic surfactants offer a huge amount of applications for industry. They are frequently used in analytical and physical chemistry. Besides, some pyridinium salts are used as disinfectants in various medical applications (e.g., eye drops, solutions, foams). In this field, quaternary pyridinium salts are compounds of high interest, on account of their similarity to benzalkonium salts [1]. Their surfactant characteristics (e.g., critical micellar concentration, surface tension) have already been determined and published everal times [2]. Some pyridinium salts (