Prenatal Stress Exposure Related to Maternal Bereavement and Risk of Childhood Overweight 英文参考文献.docVIP
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Prenatal Stress Exposure Related to Maternal Bereavement and Risk of Childhood Overweight 英文参考文献
PrenatalStressExposureRelatedtoMaternal
BereavementandRiskofChildhoodOverweight
JiongLi1*,J?rnOlsen1,2,MogensVestergaard3,4,CarstenObel4,JenniferL.Baker5,ThorkildI.A.
S?rensen5
1Department ofEpidemiology, SchoolofPublicHealth,UniversityofAarhus,Aarhus,Denmark, 2DepartmentofEpidemiology,SchoolofPublicHealth,Universityof
CaliforniaLosAngeles,LosAngeles,California,UnitedStatesofAmerica,3ResearchUnitforGeneralPractice,UniversityofAarhus,Aarhus,Denmark,4Departmentof
General Practice, School of Public Health, University of Aarhus, Aarhus, Denmark, 5Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen,
Denmark
Abstract
Background:Ithasbeensuggestedthatprenatalstresscontributestotheriskofobesitylaterinlife.Inapopulation–based
cohortstudy,weexaminedwhetherprenatalstressrelatedtomaternalbereavementduringpregnancywasassociatedwith
theriskofoverweightinoffspringduringschoolage.
Methodology/PrincipalFindings:Wefollowed65,212childrenborninDenmarkfrom1970–1989whounderwenthealth
examinationsfrom7to13yearsofageinpublicorprivateschoolsinCopenhagen.Weidentified459childrenasexposedto
prenatalstress,definedbybeingborntomotherswhowerebereavedbydeathofaclosefamilymemberfromoneyear
before pregnancy until birth of the child. We compared the prevalence of overweight between the exposed and the
unexposed. Body mass index (BMI) values and prevalence of overweight were higher in the exposed children, but not
significantly so until from 10 years of age and onwards, as compared with the unexposed children. For example, the
adjustedoddsratio(OR)foroverweightwas1.68(95%confidenceinterval[CI]1.08–2.61)at12yearsofageand1.63(95%CI
1.00–2.61)at13yearsofage.ThehighestORswereobservedwhenthedeathoccurredintheperiodfrom6to0month
beforepregnancy(OR3.31,95%CI1.71–6.42atage12,andOR2.31,95%CI1.08–4.97atage13).
Conclusions/Significance: Our results suggest that severe pre-pregnancy stress is associated with an increased risk of
overweightintheoffspringinlaterchildhood.
Citation: Li
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