Prevalence and Associations of Steep CorneaKeratoconus in Greater Beijing. The Beijing Eye Study 英文参考文献.docVIP

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Prevalence and Associations of Steep CorneaKeratoconus in Greater Beijing. The Beijing Eye Study 英文参考文献.doc

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Prevalence and Associations of Steep CorneaKeratoconus in Greater Beijing. The Beijing Eye Study 英文参考文献

PrevalenceandAssociationsofSteepCornea/ KeratoconusinGreaterBeijing.TheBeijingEyeStudy LiangXu1*,YaXingWang1,YinGuo1,QiShengYou1,JostB.Jonas1,2,theBeijingEyeStudyGroup1 1BeijingInstituteofOphthalmology,BeijingTongrenHospital,CapitalMedicalUniversity,Beijing,China,2DepartmentofOphthalmology,MedicalFacultyMannheimof theRuprecht-Karls-University,Heidelberg,Germany Abstract Purpose:Toevaluatetheprevalenceandassociatedfactorsofsteepcornea/keratoconusintheadultChinesepopulation. Methods: The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.669.8 years (range: 50–93 years). A detailed ophthalmic examination was performed including optical low-coherence reflectometry. Steepcornea/keratoconusweredefinedasananteriorcornealrefractivepowerexceeding48diopters. Results:Meanrefractivepowerofthecorneawas43.1661.45diopters(range:36.51to48.46diopters;flattestmeridian)and 43.9861.52 diopters (range: 37.00 to 52.88 diopters; steepest meridian). A steep cornea/keratoconus defined as corneal refractivepowerof$48dioptersand$49diopterswasdetectedin27subjects(prevalencerate:0.960.2%)and6(0.26 0.1%) subjects, respectively. Presence of steep cornea/keratoconus was associated with shorter axial length (P,0.001), smaller interpupillary distance (P=0.038), lower best corrected visual acuity (P=0.021), higher cylindrical refractive error (P,0.001)andmoremyopicrefractiveerror(P,0.001).Itwasnotsignificantlyassociatedwithgender,bodyheight,psychic depression, cognitive function, blood concentrations of glucose, lipids, creatinine and C-reactive protein, blood pressure andqualityoflifescore,norwithintraocularpressure,dryeyefeeling,andlensthickness. Conclusions:Asteepcornea/keratoconusdefinedascornealrefractivepowerof48+dioptershasaprevalenceof0.960.2% amongChineseaged50yearsandabove.Itsprevalencewassignificantlyassociatedwiththeocularparametersofshorter axiallength,smallerinterpupillarydistance,highercylindricalandmyopicrefractiveerrorandlowerbestcorrectedvisua