Prevalence of hepatopathy in type 1 diabetic children 英文参考文献.docVIP

Prevalence of hepatopathy in type 1 diabetic children 英文参考文献.doc

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Prevalence of hepatopathy in type 1 diabetic children 英文参考文献

Al-Hussainietal.BMCPediatrics2012,12:160 /1471-2431/12/160 RESEARCH ARTICLE OpenAccess Prevalenceofhepatopathyintype1diabetic children AbdulrahmanAAl-Hussaini1*,NimerMSulaiman2,MusaDAlZahrani2,AhmedSAlenizi2andMannanKhan3 Abstract Background:ThePrevalenceofliverdiseaseamongdiabeticshasbeenestimatedtobebetween17%and100%. Mostofthesedatawereobtainedfromadultstudies.Theaimofourstudywastoscreenforliverdiseaseamong type1diabeticchildren. Methods:Childrenwithtype1diabetesfollowinginclinichavebeenexaminedforexistenceofliverdisease,from November2008toNovember2009.Allweresubjectedtothefollowing:History,physicalexamination,liverfunction tests,fastinglipidprofile,HbA1C,andultrasoundoftheliver.Ahyperechogenicliverand/orhepatomegalyon ultrasoundwereattributedmostlikelytoexcessglycogenorfatintheliver,afternegativeextensivework-upto ruleoutotherunderlyingliverdisease. Results:106childrenwithtype1diabeteswerestudied:agerangedbetween8monthsto15.5years,sixtytwo patientswerefemales.Twentytwopatients(21%)wereidentifiedtohaveabnormalfindingsonultrasoundofthe liver:10patientshadhepatomegalyand12hadhyperechogenicliver.Thegroupwithhyperechogenicliverhad poorerglycemiccontrolthanpatientswithnormalliver(MeanHbA1c12.14%Vs10.7%;Pvalue=0.09). Hyperechogenicliverresolvedin60%at6monthsfollow-upuponachievingbetterglycemiccontrol. Conclusions:Hyperechogenicliverand/orhepatomegalyarenotuncommoninchildrenwithtype1diabetesand tendtobemoreprevalentamongchildrenwithpoorglycemiccontrol.Type1diabetesrelatedhepatopathyis reversiblebyoptimizingglycemiccontrol.Becauseofitssafety,andreliability,ultrasoundcanbeusedtoscreenfor hepatopathyintype1diabeticchild. Keywords:Fattyliver,Hepatomegaly,Hepaticglycogenosis,Type1diabetes,Diabetesmellitus,Ultrasound Background diagnosed in 63% of patients with type 2 diabetes com- Type1diabetesisadisorderofglucosemetabolismthat pared with 17% of patientswith type 1 diabetes [2].Be- resultsfrominsulindeficiencysecondarytoautoimmune cause the frequency of obesity

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