Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo 英文参考文献.docVIP
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Prevalence of Human African Trypanosomiasis in the Democratic Republic of the Congo 英文参考文献
PrevalenceofHumanAfricanTrypanosomiasisinthe
DemocraticRepublicoftheCongo
DieudonneMumba1,ElaineBohorquez2,JaneMessina3,VictorKande4,StevenM.Taylor2,AntoinetteK.
Tshefu5,JeremieMuwonga6,MelchiorM.Kashamuka2,MichaelEmch3,RichardTidwell7 ,Philippe
Bu¨scher8,StevenR.Meshnick2*
1InstitutNationaldeRechercheBiome′dicale,Kinshasa,DemocraticRepublicoftheCongo,2DepartmentofEpidemiology,UniversityofNorthCarolinaGillingsSchoolof
GlobalPublicHealth,ChapelHill,NorthCarolina,UnitedStatesofAmerica,3DepartmentofGeography,UniversityofNorthCarolina,ChapelHill,NorthCarolina,United
StatesofAmerica,4ProgrammeNationaldeLuttecontrelaTrypanosomiaseHumaineAfricaine,Kinshasa,DemocraticRepublicoftheCongo,5KinshasaSchoolofPublic
Health,UniversityofKinshasa,Kinshasa,DemocraticRepublicoftheCongo,6ProgrammeNationaldeLuttecontrelaSIDA,Kinshasa,DemocraticRepublicoftheCongo,
7DepartmentofPathologyandLaboratoryMedicine,UniversityofNorthCarolinaSchoolofMedicine,ChapelHill,NorthCarolina,UnitedStatesofAmerica,8Department
ofParasitology,InstituteofTropicalMedicine,Antwerp,Belgium
Abstract
HumanAfricanTrypanosomiasis(HAT)isamajorpublichealthproblemintheDemocraticRepublicoftheCongo(DRC).
ActiveandpassivesurveillanceforHATisconductedbutmayunderestimatethetrueprevalenceofthedisease.Weused
ELISA to screen 7,769 leftover dried blood spots from a nationally representative population-based survey, the 2007
DemographicandHealthSurvey.26sampleswerepositivebyELISA.Threeofthesewerealsopositivebytrypanolysisand/
orPCR.Fromthesedata,weestimatethattherewere18,592peoplewithHAT(95%confidenceinterval,4,883–32,302)in
theDRCin2007,slightlymorethantwiceasmanyaswerereported.
Citation:MumbaD,BohorquezE,MessinaJ,KandeV,TaylorSM,etal.(2011)PrevalenceofHumanAfricanTrypanosomiasisintheDemocraticRepublicofthe
Congo.PLoSNeglTropDis5(8):e1246.doi:10.1371/journal.pntd.0001246
Editor:DanielK.Masiga,InternationalCentreofInsectPhysiologyandEcology,Kenya
ReceivedJanuary26,2011;AcceptedJune4,2011;PublishedAugust2,2011
Copyright: ? 2011 M
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