Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats 英文参考文献.docVIP

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Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats 英文参考文献.doc

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Progestin Receptor-Mediated Reduction of Anxiety-Like Behavior in Male Rats 英文参考文献

ProgestinReceptor-MediatedReductionofAnxiety-Like BehaviorinMaleRats CatherineJ.Auger*,RobinM.Forbes-Lorman DepartmentofPsychology,UniversityofWisconsin,Madison,Wisconsin,UnitedStatesofAmerica Abstract Background:Itiswellknownprogesteronecanhaveanxiolytic-likeeffectsinanimalsinanumberofdifferentbehavioral testing paradigms. Although progesterone is known to influence physiology and behavior by binding to classical intracellular progestin receptors, progesterone’s anxiety reducing effects have solely been attributed to its rapid non- genomic effects at the GABAA receptor. This modulation occurs following the bioconversion of progesterone to allopregnanolone.Seeminglyparadoxicalresultsfromsomestudiessuggestedthatthefunctionofprogesteronetoreduce anxiety-likebehaviormaynotbeentirelyclear;therefore,wehypothesizedthatprogesteronemightalsoactuponprogestin receptorstoregulateanxiety. Methodology/PrincipalFindings:Totestthis,weexaminedtheanxiolytic-likeeffectsofprogesteroneinmaleratsusingthe elevated plus maze, a validated test of anxiety, and the light/dark chamber in the presence or absence of a progestin receptorantagonist,RU486.Herewepresentevidencesuggestingthattheanxiolytic-likeeffectsofprogesteroneinmale rats can be mediated, in part, by progestin receptors, as these effects are blocked by prior treatment with a progestin receptorantagonist. Conclusion/Significance: This indicates that progesterone can act upon progestin receptors to regulate anxiety-like behaviorinthemaleratbrain. Citation:AugerCJ,Forbes-LormanRM(2008)ProgestinReceptor-MediatedReductionofAnxiety-LikeBehaviorinMaleRats.PLoSONE3(11):e3606.doi:10.1371/ journal.pone.0003606 Editor:PaulA.Bartell,PennsylvaniaStateUniversity,UnitedStatesofAmerica ReceivedAugust15,2008;AcceptedOctober9,2008;PublishedNovember5,2008 Copyright: ? 2008 Auger, Forbes-Lorman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricteduse,distribution,andrepro