Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects 英文参考文献.docVIP

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Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects 英文参考文献.doc

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Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects 英文参考文献

Nielsenetal.ArthritisResearchTherapy2011,13:R109 /content/13/3/R109 RESEARCH ARTICLE OpenAccess Promoterpolymorphismsinthechitinase3-like1 geneinfluencetheserumconcentrationofYKL- 40inDanishpatientswithrheumatoidarthritis andinhealthysubjects KasparRNielsen1*,RudiSteffensen1,MartinBoegsted2,JohnBaech1,SoerenLundbye-Christensen3, MereteLHetland4,SophineBKrintel4,5,HansEJohnsen2,MetteNyegaard2andJuliaSJohansen5,6 Abstract Introduction:Thepresentstudyinvestigatestheassociationbetweensinglenucleotidepolymorphisms(SNPs)in thechitinase3-like1(CHI3L1)geneandserumconcentrationsofYKL-40inDanishpatientswithrheumatoid arthritis(RA)andhealthycontrolsaswellastheassociationwithRAintheDanishpopulation.TheCHI3L1geneis locatedonchromosome1q32.1andencodestheYKL-40glycoprotein.YKL-40concentrationsareelevatedinthe serumofpatientswithRAcomparedtohealthysubjects,andYKL-40hasbeensuggestedtobeanauto-antigen andmayplayaroleindevelopmentofRAandininflammation. Methods:EightSNPsintheCHI3L1geneandpromotorweregenotypedin308patientswithRAand605controls (healthyblooddonors)usingTaqManallelediscriminationassays.SerumconcentrationsofYKL-40were determinedbyanenzyme-linkedimmunosorbentassay(ELISA). Results:WefoundsignificantassociationbetweentheserumconcentrationsofYKL-40andpolymorphisminthe CHI3L1geneamongbothpatientswithRAandcontrols.Theg.-131(CG)polymorphism(rs4950928)wasmost stronglyassociatedwithageadjustedserumconcentrationsofYKL-40inpatientswithRA(P2.4e-8)andcontrols (P2.2e-16).Nosignificantallelic-orgenotypicassociationwithRAwasfoundinthisDanishcohort. Conclusions:Wesuggestthattheg.-131(CG)promoterpolymorphismhasasubstantialimpactonserum concentrationsofYKL-40inpatientswithRAandhealthysubjects.However,thepolymorphismdoesnotseemto conferrisktoRAitself.TheeffectofCHI3L1polymorphismonclinicaloutcomeortheresponsetotreatmentin patientswithRAremainstobeinvestigated. Introduction locus on chromosome 6p21.3 and a single nucleotide Rheumatoid arthritis (RA) is a systemic autoimmune polymorphism (SN