Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice 英文参考文献.docVIP

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Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice 英文参考文献.doc

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Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice 英文参考文献

PropertiesofDoublecortin-(DCX)-ExpressingCellsinthe PiriformCortexComparedtotheNeurogenicDentate GyrusofAdultMice FriederikeKlempin1.,GoloKronenberg2.,GiselleCheung3,4,HelmutKettenmann3 ,Gerd Kempermann5* 1ISCRM,InstituteforStemCellandRegenerativeMedicine,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica, 2DepartmentofNeurologyand Center for Stroke Research Berlin, Charite′ University Medicine Berlin, Berlin, Germany, 3Max-Delbru¨ck-Center for Molecular Medicine (MDC) Berlin-Buch, Berlin-Buch, Germany, 4Center for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom, 5CRTD –Center for Regenerative TherapiesDresden,TechnischeUniversita¨t Dresden,Dresden,Germany Abstract The piriform cortex receives input from the olfactory bulb and (via the entorhinal cortex) sends efferents to the hippocampus,therebyconnectingthetwocanonicalneurogenicregionsoftheadultrodentbrain.Doublecortin(DCX)isa cytoskeleton-associated proteinthat is expressed transiently in the courseof adultneurogenesis. Interestingly, the adult piriform cortex, which is usually considered non-neurogenic (even though some reports exist that state otherwise), also containsanabundantpopulationofDCX-positivecells.WeaskedhowsimilarthesecellswouldbetoDCX-positivecellsin the course of adult hippocampal neurogenesis. Using BAC-generated transgenic mice that express GFP under the DCX promoter,westudiedDCX-expressionandelectrophysiologicalpropertiesofDCX-positivecellsinthemousepiriformcortex incomparisonwiththedentategyrus.Whileoneclassofcellsinthepiriformcortexindeedshowedfeaturessimilartonewly generatedimmaturegranuleneurons,themajorityofDCXcellsinthepiriformcortexwasmatureandrevealedlargeNa+ currents and multiple action potentials. Furthermore, when proliferative activity was assessed, we found that all DCX- expressingcellsinthepiriformcortexwerestrictlypostmitotic,suggestingthatnoDCX-positive‘‘neuroblasts’’existhereas they do in the dent