Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch 英文参考文献.docVIP

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Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch 英文参考文献.doc

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Progression of Oral Squamous Cell Carcinoma Accompanied with Reduced E-Cadherin Expression but Not Cadherin Switch 英文参考文献

ProgressionofOralSquamousCellCarcinoma AccompaniedwithReducedE-CadherinExpressionbut NotCadherinSwitch TakashiHashimoto1,YuichiSoeno2,GentaMaeda1,YujiTaya2,TakaakiAoba2,MasanoriNasu3, ShuichiKawashiri4,KazushiImai1* 1DepartmentofBiochemistry,TheNipponDentalUniversity,Tokyo,Japan,2DepartmentofPathology,TheNipponDentalUniversity,Tokyo,Japan,3ResearchCenter forOdontology,TheNipponDentalUniversity,Tokyo,Japan,4DepartmentofOralSurgery,KanazawaUniversity,Kanazawa,Japan Abstract ThecadherinswitchfromE-cadherintoN-cadherinisconsideredasahallmarkoftheepithelial-mesenchymaltransitionand progressionofcarcinomas.Althoughitenhancesaggressivebehaviorsofadenocarcinomacells,thesignificanceandroleof cadherin switch in squamous cell carcinomas (SCCs) are largely controversial. In the present study, we immunohisto- chemically examined expression of E-cadherin and N-cadherin in oral SCCs (n=63) and its implications for the disease progression. The E-cadherin-positive carcinoma cells were rapidly decreased at the invasive front. The percentage of carcinomacellsstainedE-cadherinatthecellmembranewasreducedinparallelwithtumordedifferentiation(P,0.01)and enhanced invasion (P,0.01). In contrast, N-cadherin-positive cells were very limited and did not correlate with the clinicopathologicalparameters.MousetonguetumorsxenotransplantatedoralSCCcelllinesexpressingbothcadherinsin vitroreproducedthereductionofE-cadherin-positivecarcinomacellsattheinvasivefrontandthenegligibleexpressionof N-cadherin. These results demonstrate that the reduction of E-cadherin-mediated carcinoma cell-cell adhesion at the invasive front, but not the cadherin switch, is an important determinant for oral SCC progression, and suggest that the environmentssurroundingcarcinomacellslargelyaffectthecadherinexpression. Citation:HashimotoT,SoenoY,MaedaG,TayaY,AobaT,etal.(2012)ProgressionofOralSquamousCellCarcinomaAccompaniedwithReducedE-Cadherin ExpressionbutNotCadherinSwitch.PLoSONE7(10):e47899.doi:10.1371/journal.pone.00478