Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents 英文参考文献.docVIP

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Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents 英文参考文献.doc

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Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-Allergic Agents 英文参考文献

Molecules 2009, 14, 3106-3114; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Production of β-Maltooligosaccharides of α- and δ-Tocopherols by Klebsiella pneumoniae and Cyclodextrin Glucanotransferase as Anti-allergic Agents Kei Shimoda 1,*, Masaaki Akagi 2 and Hiroki Hamada 3,* 1 Department of Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879- 5593, Japan 2 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan 3 Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan * Author to whom correspondence should be addressed; E-mail: shimoda@med.oita-u.ac.jp (K.S.), hamada@das.ous.ac.jp (H.H.); Tel.: +81-97-586-5606; Fax: +81-97-586-5619 Received: 14 July 2009; in revised form: 19 August 2009 / Accepted: 20 August 2009 / Published: 20 August 2009 Abstract: The glycosylation of α- and δ-tocopherols using Klebsiella pneumoniae and cyclodextrin glucanotransferase (CGTase) was investigated. K. pneumoniae converted α- and δ-tocopherols into the corresponding β-glucosides in 10 and 8% yield, respectively. CGTase glycosylated α-tocopheryl β-glucoside to α-tocopheryl β-maltoside (51%) and α- tocopheryl β-maltotrioside (35%). On the other hand, δ-tocopheryl β-glucoside was converted into the corresponding β-maltoside (45%) and β-maltotrioside (29%) by CGTase. The β-glucoside of α-tocopherol, and β-glucoside and β-maltoside of δ-tocopherol showed inhibitory effects on IgE antibody production and on histamine release from rat peritoneal mast cells. Keywords: tocopherol; Klebsiella pneumoniae; cyclodextrin glucanotransferase; β- maltooligosaccharide; anti-allergic activity Molecules 2009, 14 3107 1. Introduction Tocopherols have been known to be essential nutrients for reproduction since 1922 [1]. They functio