Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction 英文参考文献.docVIP

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Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction 英文参考文献.doc

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Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction 英文参考文献

Available online /content/8/4/R234 Research Open Access August 2004 Vol 8 No 4 Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction Gian Paolo Castelli1, Claudio Pognani1, Michael Meisner2, Antonio Stuani1, Daniela Bellomi3 and Laura Sgarbi1 1Intensive Care, Anesthesiology and Pain Relief Unit, C Poma Hospital, Mantova, Italy 2Department of Anaesthesiology and Intensive Care Therapy, University of Jena, Germany 3Clinical Pathology Laboratory, C Poma Hospital, Mantova, Italy Corresponding author: Gian Paolo Castelli, gianpaolo.castelli@inwind.it Received: 22 November 2003 Revisions requested: 24 November 2003 Revisions received: 22 April 2004 Accepted: 4 May 2004 Critical Care 2004, 8:R234-R242 (DOI 10.1186/cc2877) This article is online at: /content/8/4/R234 ? 2004 Castelli et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Published: 10 June 2004 Abstract Introduction Both C-reactive protein (CRP) and procalcitonin (PCT) are accepted sepsis markers. However, there is still some debate concerning the correlation between their serum concentrations and sepsis severity. We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response. Patients and methods One hundred and fifty adult intensive care unit patients were observed consecutively over a period of 10 days. PCT, CRP and infection parameters were compared among the following groups: no systemic inflammatory response syndrome (SIRS) (n = 15), SIRS (n = 15), sepsis/SS (n = 71) (including sepsis, severe sepsis and septic shock [n = 34, n = 22 and n = 15]), and trauma patients (n = 49, no infection). Results