Proteomic Profiling of a Mouse Model for Ovarian Granulosa Cell Tumor Identifies VCP as a Highly Sensitive Serum Tumor Marker in Several Human Cancers 英文参考文献.docVIP
- 1、本文档共9页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Proteomic Profiling of a Mouse Model for Ovarian Granulosa Cell Tumor Identifies VCP as a Highly Sensitive Serum Tumor Marker in Several Human Cancers 英文参考文献
ProteomicProfilingofaMouseModelforOvarian
GranulosaCellTumorIdentifiesVCPasaHighlySensitive
SerumTumorMarkerinSeveralHumanCancers
Marie-Noe¨lleLague¨1.,Raphae¨lleRomieu-Mourez2.,Eric′ Bonneil3,AlexandreBoyer1,NicolasPouletty4,
`
Anne-MarieMes-Masson5,PierreThibault3,Marie-EveNadeau6,DerekBoerboom1*
1CentredeRechercheenReproductionAnimale,Faculte′deMe′decineVe′te′rinaire,Universite′deMontre′al,Montre′al,Que′bec,Canada,2LadySirMortimerB.DavisJewish
GeneralHospitalLadyDavisInstituteforMedicalResearch,Montre′al,Que′bec,Canada,3InstitutdeRecherchesurleCanceretenImmunologie,Universite′deMontreal,
Montre′al,Que′bec,Canada,4De′partementdePathologieetMicrobiologie,Faculte′ deMe′decineVe′te′rinaire,Universite′ deMontre′al, Montre′al,Que′bec,Canada,5Centre
de recherche du Centre Hospitalier de l’Universite′ de Montre′al CRCHUM and Institut du cancer de Montre′al, Montre′al, Que′bec, Canada, 6De′partement de Sciences
Cliniques,Faculte′ deMe′decineVe′te′rinaire,Universite′ deMontre′al,Montre′al, Que′bec, Canada
Abstract
Theinitialaim ofthisstudywastoidentifynovel serumdiagnosticmarkersforthehumanovariangranulosacelltumor
(GCT),atumorthatrepresentsupto5%ofallovariancancers.Tocircumventthepaucityofhumantissuesavailablefor
analyses, we used the Ctnnb1tm1Mmt/+;Ptentm1Hwu/tmiHwu;Amhr2
tm3(cre)Bhr/+
transgenic mouse model, which features the
constitutiveactivationofCTNNB1signalingcombinedwiththelossofPteningranulosacellsanddevelopsGCTsthatmimic
aggressiveformsofthehumandisease.Proteomicprofilingbymassspectrometryshowedthatvinculin,enolase1,several
heat shock proteins, and valosin containing protein (VCP) were more abundantly secreted by cultured mouse GCT cells
compared to primary cultured GC. Among these proteins, only VCP was present in significantly increased levels in the
preoperativeserumofGCTcancerpatientscomparedtonormalsubjects.TodeterminethespecificityofVCP,serumlevels
were also measured in ovarian carcinoma, non-Hodgkin’s lymphoma and breast, colon, pancr
您可能关注的文档
- Protein Meta-Functional Signatures from Combining Sequence, Structure, Evolution, and Amino Acid Property Information 英文参考文献.doc
- Protein Misfolding as an Underlying Molecular Defect in Mucopolysaccharidosis III Type C 英文参考文献.doc
- Protein Molecular Function Prediction by Bayesian Phylogenomics 英文参考文献.doc
- Protein Modularity of Alternatively Spliced Exons Is Associated with Tissue-Specific Regulation of Alternative Splicing 英文参考文献.doc
- Protein Networks as Logic Functions in Development and Cancer 英文参考文献.doc
- Protein Linewidth and Solvent Dynamics in Frozen Solution NMR 英文参考文献.doc
- Protein Nanomachines 英文参考文献.doc
- Protein profiling reveals inter-individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid 英文参考文献.doc
- Protein Scaffolds Can Enhance the Bistability of Multisite Phosphorylation Systems 英文参考文献.doc
- Protein prenyltransferases 英文参考文献.doc
文档评论(0)