Recent advances in nanoparticle formulation of oleanolic acid 英文参考文献.docVIP

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Recent advances in nanoparticle formulation of oleanolic acid 英文参考文献.doc

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Recent advances in nanoparticle formulation of oleanolic acid 英文参考文献

Chenetal.ChineseMedicine2011,6:20 /content/6/1/20 REVIEW OpenAccess Recentadvancesinnanoparticleformulationof oleanolicacid MeiwanChen?,ZhangfengZhong?,WenTan,ShengpengWangandYitaoWang* Abstract Oleanolicacid(OA)isanaturaltriterpenoidpossessinganti-inflammatory,antitumor,antiviral,hepatoprotectiveand antihyperlipidemiceffects.ResearchonthepharmacologicalactivitiesandclinicalapplicationsofOAhasmade significantprogressinthepastdecade,particularlyintheareassuchasisolationandpurification,chemical modifications,pharmacologicalresearch,toxicitystudiesandclinicaluseofOA.However,duetoitspooraqueous solubility,instabilityandlowbioavailability,OA’sclinicalapplicationsarestillratherlimited.Recently, nanoparticulatedrugdeliveryasthebiologicaldimensionofnanotechnologyhasbeendeveloped,whichmayhelp generateusefulformulationsofOAforclinicalapplications.Nanoparticulatedrugdeliverysystemenhancesthe dissolutionrateandbioavailabilityofOA,providingafeasibleformulationmethodforclinicalapplications. Introduction of solubility and stability, protection from toxicity, Oleanolicacid(OA),anaturallyoccurringpentacyclictri- enrichment ofpharmacological activities, improvement terpenoid extracted from the leaves and roots ofOlea of tissue macrophage distribution, bioavailability and europaea,ViscumalbumL.,AraliachinensisL.andover sustaineddelivery,protectionfromphysicalandchemi- 120otherplantspecies [1],ischemically knownas3b- caldegradation[7,11]. hydroxy-olea-12-en-28-oic acid[2](Figure1).OAexhi- Thisarticlereviewsrecentadvancesinnanoparticulate bitsmanybiologicalactivitiessuchasanti-inflammatory, formulationofOA. antitumor,antiviral,hepatoprotectiveandanti-hyperlipi- demiceffects.OAhasbeenusedinChinesemedicineto Solid lipid nanoparticles treatliverdisorders forover20years[2].Conventional Solid lipid nanoparticles (SLN), which remain solid at formulationsofOAaretabletsandcapsules[3];however, roomtemperature,haveemergedasanewpharmaceuti- OA’spooraqueous solub