Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster 英文参考文献.docVIP

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Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster 英文参考文献.doc

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Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster 英文参考文献

Open Access Re rch 2003LockeetVoal.lumesea4, Issue 8, Article R50 Refinement of a chimpanzee pericentric inversion breakpoint to a segmental duplication cluster Devin P Locke*, Nicoletta Archidiacono?, Doriana Misceo?, Maria Francesca Cardone?, Stephane Deschamps?, Bruce Roe?, Mariano Rocchi? and Evan E Eichler* Addresses: *Department of Genetics, Center for Computational Genomics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA. ?Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, University of Bari, Bari 70126, Italy. ?Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA. Correspondence: Evan E Eichler. E-mail: eee@ Published: 15 July 2003 Received: 5 March 2003 Revised: 29 April 2003 Accepted: 16 June 2003 Genome Biology 2003, 4:R50 The electronic version of this article is the complete one and can be found online at /2003/4/8/R50 ? 2003 Locke et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. RefinementPcftuihevsireimocbnpeonaeuntvnrzeidecnaetir.nofkiRevaseaerrypfchimpanzeesoorirotomydnpuseacastdriaivefefrteehirsesoupericentricmbllatytooinsoftinhncyaeobnmsrduimdcinversionshuostbnesveeeiuqlnicutthyser,nbreakpointoitnmsapdetidcciiatcthoiornontotmoaroasesesegmentalotvhmeoraaullgdchoifnfteosrduplicationtebitneuctehivseeaphmoetoteennclusterrgtoihumanscahl roesmualttiandocfipnectherriecaegreatsnetsriacnapes.idnvoenresTheicohnrsohuman,masorseopmrandoalduc- Abstract Background: Pericentric inversions are the most common euchromatic chromosomal differences among humans and the great apes. The human and chimpanzee karyotype differs by nine such events, in addition to several constitutive heterochro