Regrowing the Adult Brain NF-κB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus 英文参考文献.docVIP

下载本文档

3
0
约6.14万字
约 13页
2017-05-13 发布于上海
举报
版权申诉

Regrowing the Adult Brain NF-κB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Regrowing the Adult Brain NF-κB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus 英文参考文献

RegrowingtheAdultBrain:NF-kBControlsFunctional CircuitFormationandTissueHomeostasisintheDentate Gyrus YvonneImielski1,JensC.Schwamborn2,PatrickLu¨ningschro¨r3,PeterHeimann3,MagdalenaHolzberg1, HendrikjeWerner4,5,OliverLeske6,AndreasW.Pu¨schel4,SylvieMemet7,RolfHeumann6,AlainIsrael8, ChristianKaltschmidt3,BarbaraKaltschmidt1* 1Molecular Neurobiology, Faculty of Biology, University of Bielefeld, Bielefeld, Germany, 2AG Stammzellbiologie und Regeneration, Institut fu¨r Zellbiologie, ZMBE, Mu¨nster,Germany;Bielefeld,Germany,3CellBiology,FacultyofBiology,UniversityofBielefeld,Bielefeld,Germany, 4Institutfu¨rMolekulareZellbiologie,Westfa¨lische Wilhelms-Universita¨t Mu¨nster,Mu¨nster,Germany,5InstituteofMedicalBiology,Immunos,Singapore,6MolekulareNeurobiochemie,Ruhr-Universita¨t Bochum,Bochum, Germany,7InstitutPasteur,Unite′ deMycologieMole′culaire, CNRSURA3012,Paris,France,8InstitutPasteur,Unite′ deSignalisationMole′culaire etActivationCellulaire, CNRSURA2582,Paris,France Abstract Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus,whichcouldberegeneratedbyadultneurogenesis.HereweshowthatgeneticablationofNF-kBresultedin severe defects in the neurogenic region (dentate gyrus) of the hippocampus. Despite increased stem cell proliferation, axogenesis,synaptogenesisandneuroprotectionwerehampered,leadingtodisruptionofthemossyfiberpathwayandto atrophyofthedentategyrusduringaging.Here,NF-kBcontrolsthetranscriptionofFOXO1andPKA,regulatingaxogenesis. Structuraldefectsculminatedinbehavioralimpairmentsinpatternseparation.Re-activationofNF-kBresultedinintegration ofnewbornneurons,finallytoregenerationofthedentategyrus,accompaniedbyacompleterecoveryofstructuraland behavioraldefects.ThesedataidentifyNF-kBasacrucialregulatorofdentategyrustissuehomeostasissuggestingNF-k Bto beatherapeutictargetfortreatingcognitiveandmooddisorders. Citation: Imielski Y, Schwamborn JC, Lu¨ningschro¨r P, He