Regulation of p53 Stability and Apoptosis by a ROR Agonist 英文参考文献.docVIP

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Regulation of p53 Stability and Apoptosis by a ROR Agonist 英文参考文献.doc

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Regulation of p53 Stability and Apoptosis by a ROR Agonist 英文参考文献

Regulationofp53StabilityandApoptosisbyaROR Agonist YongjunWang,LauraA.Solt,DouglasJ.Kojetin,ThomasP.Burris* TheScrippsResearchInstitute,Jupiter,Florida,UnitedStatesofAmerica Abstract Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti- cancertherapeuticagents.Here,wedescribeanovelmechanismforstabilizationofp53proteinexpressionviaactivationof theorphannuclearreceptor,RORa.WedemonstratethattreatmentofcancercellswithanewlydescribedsyntheticROR agonist,SR1078,leadstop53stabilizationandinductionofapoptosis.ThesedatasuggestthatsyntheticRORagonistsmay holdutilityinthetreatmentofcancer. Citation: Wang Y, Solt LA, Kojetin DJ, Burris TP (2012) Regulation of p53 Stability and Apoptosis by a ROR Agonist. PLoS ONE 7(4): e34921. doi:10.1371/ journal.pone.0034921 Editor:AndreiL.Gartel,UniversityofIllinoisatChicago,UnitedStatesofAmerica ReceivedMarch18,2011;AcceptedMarch10,2012;PublishedApril11,2012 Copyright: ? 2012 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbytheNationalInstitutesofHealth(NIH)DK089984,MH092769.Thefundershadnoroleinstudydesign,datacollectionand analysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:tburris@ Introduction reports we focused on identification of pathways where RORa mayregulatecellproliferation. In approximately 50% of human cancers the p53 gene is mutated, but in the remaining half of cancers activation of p53 functionisconsideredtobeavaluablestrategyfordevelopmentof anti-cancer therapeutics. p53 plays a critical role in limiting cell proliferationandinducingapoptosisinresponsetocellularstress/ damageandabnormalfunctionofp53isassociatedwithcancers [1]. p53 function is tightly regulated