Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins 英文参考文献.docVIP

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Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins 英文参考文献.doc

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Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins 英文参考文献

Open Access Re rch 2005FreilichetVoal.lumesea6, Issue 7, Article R56 Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins Shiri Freilich*, Tim Massingham*, Sumit Bhattacharyya?, Hannes Ponstingl*, Paul A Lyons?, Tom C Freeman* and Janet M Thornton* Addresses: *EMBL-EBI, Wellcome Trust Genome Campus, Cambridge, CB10 1SB, UK. ?Rosalind Franklin Centre Genomics Research, Wellcome Trust Genome Campus, Cambridge, CB10 1SB, UK. Correspondence: Shiri Freilich. E-mail: shirigo@ebi.ac.uk Published: 29 June 2005 Received: 17 February 2005 Revised: 11 April 2005 Accepted: 11 May 2005 Genome Biology 2005, 6:R56 (doi:10.1186/gb-2005-6-7-r56) The electronic version of this article is the complete one and can be found online at /2005/6/7/R56 ? 2005 Freilich et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License /licenses/by/2.0 Relationshipagpe(Aanmdicnrootafabetweenurnayctaionna)lygene-expressionissisthoef mdoomusineagnetnprofilefeaecxtoprresandshsaiopnifunctionncgotmhbeienxeandpdrwesiphyleticstihotnhperpororiginfoleteoinf sainfpurnmouseoctionaltein./andp phyletic classification suggests that phyletic Abstract Background: The combination of complete genome sequence information with expression data enables us to characterize the relationship between a proteins evolutionary origin or functional category and its expression pattern. In this study, mouse proteins were assigned into functional and phyletic groups and the gene expression patterns of the different protein groupings were examined by microarray analysis in various mouse tissues. Results: Our results suggest that the proteins that are universally distributed in all tissues are predominantly enzymes and transporters. In contrast, the tissue-specific set is dominated by regulatory proteins (signal transduction and transcriptio