维持性血液透析患者血管转移性钙化危险因素分析.pdfVIP

.564. lournal 01 Clinical and Experimental Medicine Vol. 12 , No.8 Apr.2013 维持性血液透析患者血管转移性钙化危险因素分析 E盟 王刚 张东亮 刘文虎. (首都医科大学附属北京友谊医院肾内科 首都医科大学肾病学系 北京 l∞050) [摘要] 目的 回顾性研究单个血液透析中心接受维持性血液透析(MHD) 患者发生转移性钙化的危险因素。方 法 纳入 123 例 MHD 患者，对2∞3 年 1 月至2012 年 12 月随访 10 年间发生的首要终点事件:全因死亡和心脑血管疾 病死亡(如:急性心肌梗死、脑卒中等)及次要终点事件:影像学检查发现转移性钙化证据(胸片提示主动脉寻钙化、政平 片提示腹主动脉钙化、超声心动图提示心脏瓣膜钙化)的相关因素进行 cox 回归检验，分析临床终点事件的危险因素。 结果 会因死亡的独立危险因素为男性(HR =0. 225 , P 0.001)和低血清白蛋白水平(HR=0.041 ， P =0. ∞1) ;心脑 血管因素死亡的独立危险因素为:男性(HR = O. 035 , P = O. 035 )、高钙磷乘积( HR = l. 678 , P = O. 049) 、血钙水平低 (HR =0.020 , P =0.030); 转移性钙化的独立危险因素只有2∞3 年时患者的透析龄(HR=0.693 ， P 0. ∞1 )。结论 透析时间越长，MHD 患者发生转移性血管钙化的风险越高。 [关键词] 血液透析矿物质和骨异常转移，1生钙化病死率心血管疾病 Tbe independent risk factors of transference calcification in maintenance bemodialysis patients. WANG Gαng ， ZHANG Dong - liang , UU Wen - hu . Department 01 Nephrology , Beijing Friendship Hospital , Capital Medical University , Beijing 1 创XJ50 ， China. (Abstract] 0时ective To study the risk facto四 of transference calcification in maintenance hemodialysis (MHD) patients. Metbods 币le retrospective study enrolled 123 MHD patients in one HD center , who were followed up for 10 years from January 2∞3 to Decernher 2012ηE COXs regression w出 used to analyze the risk factors on the clinical outcomes , which included the primary events (all - cause mortality and cadio - cerebrovascular disease mortality) and the secondary events ( transference calcification) .币le evidences of transference calcification were defined as aortic arch calcification (AoAC) , aorta abdominalis calcification (AAC) , and cardiac valve calcification (CVC) , which detected by plain chest radiography , lateral abdominal plain film and echocardiogr田1 ， respectively. R臼u