PhenomiR a knowledgebase for microRNA expression in diseases and biological processes 英文参考文献.docVIP

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PhenomiR a knowledgebase for microRNA expression in diseases and biological processes 英文参考文献.doc

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PhenomiR a knowledgebase for microRNA expression in diseases and biological processes 英文参考文献

Rueppetal.GenomeBiology2010,11:R6 /2010/11/1/R6 SOFTWARE OpenAccess PhenomiR:aknowledgebaseformicroRNA expressionindiseasesandbiologicalprocesses AndreasRuepp1*,AndreasKowarsch1,DanielSchmidl1,2,FelixBuggenthin1,BarbaraBrauner1,IrmtraudDunger1, GiselaFobo1,GoarFrishman1,CorinnaMontrone1,FabianJTheis1,2* Abstract Inrecentyears,microRNAshavebeenshowntoplayimportantrolesinphysiologicalaswellasmalignantpro- cesses.ThePhenomiRdatabasehttp://mips.helmholtz-muenchen.de/phenomirprovidesdatafrom542studiesthat investigatederegulationofmicroRNAexpressionindiseasesandbiologicalprocessesasasystematic,manually curatedresource.UsingthePhenomiRdataset,wecoulddemonstratethat,dependingondiseasetype,indepen- dentinformationfromcellculturestudiescontrastswithconclusionsdrawnfrompatientstudies. Rationale cancer types solely by miRNA expression profiles MicroRNAs(miRNAs)areapproximately22-nucleotide [10,11]. In recent years, deregulated expression of endogenous RNAspredicted toregulate theexpression miRNA has also been found to be associated with of most mammalian genes [1]. Since the discovery of humandiseases suchascardiomyopathy, muscular dis- miRNAs in Caenorhabditis elegans, the influence of orders and neurodegenerative diseases [12-14]. The these regulatory RNAs on cellular processes has been samples used for these studies stem from biopsies of established in a large variety of metazoa [2]. Accord- patients orcell cultures, whichareusedaseasily tract- ingly,individualstudiesaswellaslarge-scaleendeavors ableexperimentalmodels.Besidesdiseases,microRNAs havedetectedagrowingnumberofmiRNAs[3,4],upto are also known to have functional roles in eukaryotic 695inhumanaccordingtomiRBaserelease12.0[5].A organisms. MicroRNA-mediated gene silencing was proteome study that investigated the influence of the showntobeinvolvedinanumberofcellularprocesses, abundance of a single miRNA on cells found that the such as cell growth, larval development and B-cell dif- modeof