PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism 英文参考文献.docVIP
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PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism 英文参考文献
PPARgamma2PreventsLipotoxicity
byControllingAdiposeTissueExpandability
andPeripheralLipidMetabolism
Gema Medina-Gomez1,Sarah L.Gray1,Laxman Yetukuri2,Kenju Shimomura3,Sam Virtue1,Mark Campbell1,
R.Keira Curtis1,Mercedes Jimenez-Linan1,Margaret Blount1,Giles S.H.Yeo1,Miguel Lopez1,
Tuulikki Seppa¨nen-Laakso2,Frances M.Ashcroft3,Matej Oresˇicˇ2,Antonio Vidal-Puig1*
1 Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke’s Hospital, Cambridge, United Kingdom, 2 Technical Research Centre of
Finland(VTT),Espoo,Finland,3UniversityLaboratoryofPhysiology,UniversityofOxford,Oxford,UnitedKingdom
Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg.
AblationofPPARg2intheob/obbackground,PPARg2à/àLepob/Lepob (POKOmouse),resultedindecreasedfatmass,
severe insulin resistance, b-cell failure, and dyslipidaemia. Our results indicate that the PPARg2 isoform plays an
importantrole,mediatingadiposetissueexpansioninresponsetopositiveenergybalance.Lipidomicanalysessuggest
that PPARg2 plays an important antilipotoxic role when induced ectopically in liver and muscle by facilitating
deposition of fat as relatively harmless triacylglycerol species and thus preventing accumulation of reactive lipid
species.OurdataalsoindicatethatPPARg2mayberequiredfortheb-cellhypertrophicadaptiveresponsetoinsulin
resistance. In summary, the PPARg2 isoform prevents lipotoxicity by (a) promoting adipose tissue expansion, (b)
increasingthelipid-bufferingcapacityofperipheralorgans,and(c)facilitatingtheadaptiveproliferativeresponseofb-
cellstoinsulinresistance.
Citation:Medina-GomezG,GraySL,YetukuriL,ShimomuraK,VirtueS,etal.(2007)PPARgamma2preventslipotoxicitybycontrollingadiposetissueexpandabilityand
peripherallipidmetabolism.PLoSGenet3(4):e64.doi:10.1371/journal.pgen.0030064
The nuclear receptor peroxisome proliferator activated
receptor gamma (PPARg) is critically required for adipo-
Introduction
An adipocent
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