Sensors and Biosensors for the Determination of Small Molecule Biological Toxins 英文参考文献.docVIP

Sensors 2008, 8, 6045-6054; DOI: 10.3390/s8096045 OPEN ACCESS sensors ISSN 1424-8220 /sensors Review Sensors and Biosensors for the Determination of Small Molecule Biological Toxins Xiang-Hong Wang 1, 2 and Shuo Wang 1,* 1 Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300222, P.R. China 2 Faculty of Food Science and Technology, Agricultural University of Hebei, Baoding 071001, Hebei, P.R. China * Author to whom correspondence should be addressed; Email: s.wang@ (S.W.); Tel.: (+86 022) 6060 1456; Fax: (+86 022) 6060 1332 Received: 19 July 2008; in revised form: 3 September 2008 / Accepted: 5 September 2008 / Published: 26 September 2008 Abstract: The following review of sensors and biosensors focuses on the determination of commonly studied small molecule biological toxins, including mycotoxins and small molecule neurotoxins. Because of the high toxicity of small molecule toxins, an effective analysis technique for determining their toxicity is indispensable. Sensors and biosensors have emerged as sensitive and rapid techniques for toxicity analysis in the past decade. Several different sensors for the determination of mycotoxins and other small molecule neurotoxins have been reported in the literature, and many of these sensors such as tissue biosensors, enzyme sensors, optical immunosensors, electrochemical sensors, quartz crystal sensors, and surface plasmon resonance biosensors are reviewed in this paper. Sensors are a practical and convenient monitoring tool in the area of routine analysis, and their specificity, sensitivity, reproducibility and analysis stability should all be improved in future work. In addition, accuracy field portable sensing devices and multiplexing analysis devices will be important requirement for the future. Keywords: Review; sensors; small molecule biological toxin.  Sensors 2008, 8 6046