Sequences to systems 英文参考文献.docVIP

Kellis and Rinn Genome Biology 2010,11:303 /2010/11/5/303 MEE TING REPORT Sequences to systems Manolis Kellis and John L Rinn * 1,2 1,3,4 in the context of human disease by the second keynote speaker, Kevin Struhl (Havard Medical School, Boston, USA). By dissecting the transcriptional circuits respond- ing to Src signaling that can yield stably transformed cells, Struhl uncovered a feedback loop mediated by the transcription factor NFκB that is sustainable for many generations in the absence of further signaling. Struhl went further to demonstrate that this pathway is Abstract A report of the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression, 23-27 March 2010, Cold Spring Harbor, USA. From a chemical standpoint, a cell can seem as a densely intertwined mess of molecules, but their emergent targetable using FDA-approved drugs, opening up novel systems-level properties exhibit structure, coordination and order, leading to the orchestrated complexity we call life. As the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression at the Cold Spring avenues of cancer therapeutics. Parsing the genome e study of any system begins with a comprehensive list Harbor Laboratory showcased, systems biology aims to of parts and their interactions, and so a major theme of bridge the vast gap of knowledge between the pairwise the meeting was the mapping of the building blocks of molecular interactions of individual cellular components and the large-scale behavior of cellular circuits that result from their synergism. e talks given at the meeting exempli?ed a new de?nition of systems biology, where genomic technologies can revolutionize our under stand- ing of classical problems by enabling molecular inter- actions to be linked to systems beha