Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients 英文参考文献.docVIP
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Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients 英文参考文献
Available online /content/13/3/R95
Research
Open Access
Vol 13 No 3
Serum resistin levels in critically ill patients are associated with
inflammation, organ dysfunction and metabolism and may predict
survival of non-septic patients
Alexander Koch1*, Olav A Gressner2*, Edouard Sanson1, Frank Tacke1* and Christian Trautwein1*
1Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
2Institute of Clinical Chemistry and Pathobiochemistry, RWTH-University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
* Contributed equally
Corresponding author: Alexander Koch, akoch@ukaachen.de
Received: 2 Apr 2009 Revisions requested: 14 May 2009 Revisions received: 27 May 2009 Accepted: 19 Jun 2009 Published: 19 Jun 2009
Critical Care 2009, 13:R95 (doi:10.1186/cc7925)
This article is online at: /content/13/3/R95
? 2009 Koch et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Blood glucose levels and insulin resistance in
critically ill patients on admission to intensive care units (ICUs)
have been identified as factors influencing mortality. The
pathogenesis of insulin resistance (IR) in critically ill patients is
complex and not fully understood. Resistin is a hormone mainly
derived from macrophages in humans and from adipose tissue
in rodents, which regulates glucose metabolism and insulin
sensitivity. In non-critically ill patients, resistin was found to be
related to impaired glucose tolerance, insulin resistance,
metabolic syndrome, obesity and type 2 diabetes. Therefore,
resistin might represent a link between inflammation, acute
phase response and insulin resistance in critically ill patients.
We aimed t
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