Serum urate, menopause, and postmenopausal hormone use from eminence to evidence-based medicine 英文参考文献.docVIP

Available online /content/10/5/120 Editorial Serum urate, menopause, and postmenopausal hormone use: from eminence to evidence-based medicine Angelo L Gaffo1 and Kenneth G Saag2 1Birmingham VA Medical Center, 700 19th Street South, Birmingham, AL 35233, USA 2Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, FOT 820, 1530 3rd Avenue South, Birmingham, AL 35294, USA Corresponding author: Kenneth G Saag, ksaag@ Published: 17 October 2008 Arthritis Research Therapy 2008, 10:120 (doi:10.1186/ar2524) This article is online at /content/10/5/120 ? 2008 BioMed Central Ltd See related research article by Hak and Choi, /content/10/5/R116 Abstract In this context, Hak and Choi present data from a large and representative sample of 7,662 women in the United States – the Third National Health and Nutritional Examination Survey [1]. Using a cross-sectional design, the study evaluates the relation between menopause (natural and surgically induced), postmenopausal hormone use, and serum urate levels. The relationship between serum urate, menopause, and aging has not been clearly defined by scientific evidence. In the present issue of Arthritis Research and Therapy , Hak and Choi present a cross- sectional analysis to clarify the effect of menopause and hormone replacement therapy on serum urate in women within the Third National Health and Nutritional Examination Survey. Menopause increased serum urate and hormone replacement therapy signifi- cantly decreased serum urate, although the overall level of change was small. The implications of these urate changes on gout and cardiovascular disease outcomes require further study. The main strength of the study is its careful methodology, including a thorough assessment of potential confounders such as age, body mass index, medication use, comorbidities, and dietary factors. After multivariate adjustment, menopause was found to