Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle 英文参考文献.docVIP

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Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle 英文参考文献.doc

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Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle 英文参考文献

Open Access Re 2009CastellanoetVoal.lumesea10,rchIssue 11, Article R123 Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle Esther Castellano*?, Carmen Guerrero*, Alejandro Nú?ez*, Javier De Las Rivas* and Eugenio Santos* Addresses: *Centro de Investigación del Cáncer, IBMCC (CSIC-USAL), University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain. ?Current address: Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincolns Inn Fields, London WC2A 3PX, UK. Correspondence: Eugenio Santos. Email: esantos@usal.es Published: 6 November 2009 Received: 2 July 2009 Accepted: 6 November 2009 Genome Biology 2009, 10:R123 (doi:10.1186/gb-2009-10-11-r123) The electronic version of this article is the complete one and can be found online at /2009/10/11/R123 ? 2009 Castellano et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. RasmpouTisoformsseracnesllcrciypcandtlieon/theaplancelld fucyclenctional analysis reveals that the H-Ras and N-Ras isoforms have different roles in the initial phases of the Abstract Background: Using oligonucleotide microarrays, we compared transcriptional profiles corresponding to the initial cell cycle stages of mouse fibroblasts lacking the small GTPases H-Ras and/or N-Ras with those of matching, wild-type controls. Results: Serum-starved wild-type and knockout ras fibroblasts had very similar transcriptional profiles, indicating that H-Ras and N-Ras do not significantly control transcriptional responses to serum deprivation stress. In contrast, genomic disruption of H-ras or N-ras, individually or in combination, determined specific differenti